Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.35 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL923979 | 0.77 | BRD4 (0.36) | BRD4BAZ2AALDH1A1SMN1; SMN2 | |
| SCHEMBL28746277 | 0.75 | BRD4 (0.35) | BRD4BAZ2AALDH1A1SMN1; SMN2 | |
| SCHEMBL28941744 | 0.73 | BRD4 (0.34) | BRD4ALDH1A1 | |
| SCHEMBL16644650 | 0.71 | CNOT7 (0.38) | BRD4BAZ2AALDH1A1 | |
| SCHEMBL859740 | 0.70 | BRD4 (0.39) | BRD4BAZ2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4868011 | 0.69 | CRHR1 (0.42) | — | |
| SCHEMBL644097 | 0.68 | ALDH1A1 (0.59) | BRD4ALDH1A1SMN1; SMN2 | |
| SCHEMBL16640633 | 0.66 | BRD4 (0.43) | BRD4ALDH1A1SMN1; SMN2 | |
| SCHEMBL18866838 | 0.62 | ALDH1A1 (0.32) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL13515074 | 0.62 | ALDH1A1 (0.33) | ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7319100-B2 | Substituted pyrazinones, pyridines and pyrimidines as corticotropin releasing factor ligands | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2008-01-15 | — | — | US | disclosed |
| US-20070155740-A1 | SUBSTITUTED PYRAZINONES, PYRIDINES AND PYRIMIDINES AS CORTICOTROPIN RELEASING FACTOR LIGANDS | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-07-05 | — | — | US | disclosed |
| US-7205306-B2 | Substituted pyrazinones, pyridines and pyrimidines as corticotropin releasing factor ligands | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2007-04-17 | — | — | US | disclosed |
| EP-1392309-B1 | SUBSTITUTED PYRAZINONES, PYRIDINES AND PYRIMIDINES AS CORTICOTROPIN RELEASING FACTOR LIGANDS | BRISTOL MYERS SQUIBB CO (US) | 2007-01-17 | — | — | EP | disclosed |
| US-20030171380-A1 | Substituted pyrazinones, pyridines and pyrimidines as corticotropin releasing factor ligands | BRISTOL-MYERS SQUIBB PHARMA COMPANY, (FORMERLY D/B/A DUPONT PHARMACEUTICALS COMPANY) | 2003-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171380-A1 | Substituted pyrazinones, pyridines and pyrimidines as corticotropin releasing factor ligands | CRH, CRHR1, CRHR2 | BRD4 1845/4885BAZ2A 2066/4885ALDH1A1 2333/4885 |
| US-20070155740-A1 | SUBSTITUTED PYRAZINONES, PYRIDINES AND PYRIMIDINES AS CORTICOTROPIN RELEASING FACTOR LIGANDS | CRH, CRHR1, CRHR2 | BRD4 1788/4885BAZ2A 1904/4885ALDH1A1 2429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.