Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.47 |
| ▸ | HTR1A | P08908 | 5/20 | 0.47 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2045879 | 0.86 | RBP4 (0.37) | HTR2C | |
| SCHEMBL1513147 | 0.81 | HTR2C (0.55) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL5075574 | 0.81 | PTGDR2 (0.46) | — | |
| Hydrochloric Acid SCHEMBL4739383 | 0.80 | HTR2C (0.56) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL30493303 | 0.80 | HTR2C (0.72) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL12981278 | 0.77 | HTR2C (0.50) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL20139888 | 0.76 | HTR2C (0.49) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL614050 | 0.75 | HTR2C (0.60) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL28086725 | 0.74 | HTR2C (0.59) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A | |
| Trifluoroacetic Acid SCHEMBL30409897 | 0.74 | KDM1A (0.56) | HTR2CSLC6A2SLC6A4SLC6A3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080070868-A1 | Novel Thiazole Inhibitors of Fructose 1,6-bisphosphatase | METABASIS THERAPEUTICS, INC. (US) | 2008-03-20 | — | — | US | claimed |
| US-20070225259-A1 | Novel Thiazole Inhibitors of Fructose 1,6-Bishosphatase | METABASIS THERAPEUTICS, INC. | 2007-09-27 | — | — | US | claimed |
| US-20080070868-A1 | Novel Thiazole Inhibitors of Fructose 1,6-bisphosphatase | METABASIS THERAPEUTICS, INC. (US) | 2008-03-20 | — | — | US | disclosed |
| US-20070225259-A1 | Novel Thiazole Inhibitors of Fructose 1,6-Bishosphatase | METABASIS THERAPEUTICS, INC. | 2007-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225259-A1 | Novel Thiazole Inhibitors of Fructose 1,6-Bishosphatase | FBP1, PFKFB1, ALDOA | HTR2C 3349/4885SLC6A2 1835/4885SLC6A4 881/4885 |
| US-20080070868-A1 | Novel Thiazole Inhibitors of Fructose 1,6-bisphosphatase | FBP1, ALDOA, SLC5A1 | HTR2C 3859/4885SLC6A2 1804/4885SLC6A4 1045/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.