Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 7/20 | 0.45 |
| ▸ | AVPR1A | P37288 | 7/20 | 0.45 |
| ▸ | CNR1 | P21554 | 5/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4873206 | 0.91 | CNR1 (0.48) | CNR1NR1H2NR1H3GRM2MEN1 | |
| SCHEMBL4867917 | 0.88 | CNR1 (0.56) | AVPR2AVPR1ACNR1MEN1KMT2A | |
| SCHEMBL4861793 | 0.86 | CNR1 (0.46) | AVPR2AVPR1ACNR1NR1H2NR1H3 | |
| SCHEMBL14280862 | 0.85 | CNR1 (0.42) | AVPR2AVPR1ACNR1CNR2 | |
| SCHEMBL4874621 | 0.83 | CNR1 (0.40) | AVPR2AVPR1ACNR1CNR2 | |
| SCHEMBL4886271 | 0.82 | ARF6 (0.43) | CNR1CHRM5CHRM3GRM2CNR2 | |
| SCHEMBL4870438 | 0.81 | CNR1 (0.38) | AVPR2AVPR1ACNR1CNR2 | |
| SCHEMBL4871547 | 0.81 | CNR1 (0.56) | CNR1GRM2MEN1KMT2ALMNA | |
| SCHEMBL4865103 | 0.80 | CNR1 (0.55) | AVPR2AVPR1ACNR1GRM2MEN1 | |
| SCHEMBL4864078 | 0.79 | CNR1 (0.59) | AVPR2AVPR1ACNR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7317012-B2 | Bicyclic heterocycles as cannabinoind-1 receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-08 | — | — | US | disclosed |
| US-7317012-B2 | Bicyclic heterocycles as cannabinoind-1 receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-08 | — | — | US | disclosed |
| US-7317012-B2 | Bicyclic heterocycles as cannabinoind-1 receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-08 | — | — | US | disclosed |
| WO-2006138656-A2 | BICYCLIC HETEROCYCLES AS CANNABINOID-1 RECEPTOR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-12-28 | — | — | WO | disclosed |
| US-20060287322-A1 | Bicyclic heterocycles as cannabinoind-1 receptor modulators | BRISTOL-MYERS SQUIBB COMPANY | 2006-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287322-A1 | Bicyclic heterocycles as cannabinoind-1 receptor modulators | CNR1, CNR2, GPR18 | AVPR2 59/4885AVPR1A 40/4885CNR1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.