Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 13/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14256333 | 1.00 | REN (0.38) | RENADORA2BALOX5 | |
| SCHEMBL14255938 | 0.83 | REN (0.42) | RENADORA2B | |
| SCHEMBL14256314 | 0.82 | ADORA2B (0.33) | ADORA2BALOX5 | |
| SCHEMBL6619803 | 0.80 | REN (0.40) | RENADORA2BALOX5 | |
| SCHEMBL14256332 | 0.80 | REN (0.40) | RENADORA2BALOX5 | |
| SCHEMBL6624668 | 0.78 | REN (0.38) | RENADORA2B | |
| SCHEMBL14256334 | 0.78 | REN (0.38) | RENADORA2B | |
| SCHEMBL4873583 | 0.77 | REN (0.55) | REN | |
| SCHEMBL14256328 | 0.77 | BRD4 (0.39) | RENADORA2B | |
| SCHEMBL14256320 | 0.77 | REN (0.55) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448200-A2 | (4-PHENYL)PIPERIDIN-3-YL-PHENYLCARBOXYLATE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-08-25 | — | — | EP | claimed |
| WO-2003043987-A2 | (4-PHENYL) PIPERIDIN-3-YL-PHENYLCARBOXYLATE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2003-05-30 | — | — | WO | claimed |
| US-7338965-B2 | 3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines | PHARMACIA & UPJOHN COMPANY (US) | 2008-03-04 | — | — | US | disclosed |