Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 12/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14256334 | 1.00 | REN (0.38) | RENADORA2BADORA1CYP1A2CYP2C9 | |
| SCHEMBL6619803 | 0.88 | REN (0.40) | RENADORA2BADORA1 | |
| SCHEMBL14256332 | 0.88 | REN (0.40) | RENADORA2BADORA1 | |
| SCHEMBL14255938 | 0.86 | REN (0.42) | RENADORA2BCYP1A2CYP2C9MAPK1 | |
| SCHEMBL14256319 | 0.82 | ADORA2B (0.32) | ADORA2BADORA1CYP1A2CYP2C9MAPK1 | |
| SCHEMBL14255937 | 0.78 | ALOX5 (0.35) | RENADORA2BADORA1 | |
| SCHEMBL4872299 | 0.78 | REN (0.38) | RENADORA2B | |
| SCHEMBL14256333 | 0.78 | REN (0.38) | RENADORA2B | |
| SCHEMBL14256327 | 0.77 | REN (0.55) | REN | |
| SCHEMBL4874348 | 0.77 | REN (0.55) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448200-A2 | (4-PHENYL)PIPERIDIN-3-YL-PHENYLCARBOXYLATE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Elan Pharmaceuticals, Inc. (US) | 2004-08-25 | — | — | EP | claimed |
| WO-2003043987-A2 | (4-PHENYL) PIPERIDIN-3-YL-PHENYLCARBOXYLATE DERIVATIVES AND RELATED COMPOUNDS AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. (US) | 2003-05-30 | — | — | WO | claimed |