Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4909942 | 1.00 | HPGD (0.47) | HPGDALDH1A1POLBGAASLC6A2 | |
| SCHEMBL4873782 | 1.00 | HPGD (0.47) | HPGDALDH1A1POLBGAASLC6A2 | |
| SCHEMBL10141182 | 0.92 | HPGD (0.46) | HPGDALDH1A1POLBGAASLC6A2 | |
| SCHEMBL10147111 | 0.85 | HPGD (0.41) | HPGDALDH1A1TDP1TNKSTNKS2 | |
| SCHEMBL16984372 | 0.81 | MKNK1 (0.48) | HPGDPOLBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL16984353 | 0.79 | SLC6A2 (0.53) | HPGDPOLBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22918217 | 0.78 | HPGD (0.44) | HPGDALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4870454 | 0.77 | MAPT (0.39) | TDP1NPSR1 | |
| SCHEMBL4871362 | 0.77 | MAPT (0.39) | TDP1NPSR1 | |
| Hydrochloric Acid SCHEMBL4912494 | 0.75 | MAPT (0.38) | NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423059-B2 | Pharmaceutically active compounds and methods of use | WYETH (US) | 2008-09-09 | — | — | US | disclosed |
| US-20050209222-A1 | Pharmaceutically active compounds and methods of use | CAMBRIDGE NEUROSCIENCE, INC. | 2005-09-22 | — | — | US | disclosed |
| US-6756389-B2 | CENTRAL NERVOUS SYSTEM DISORDERS | CAMBRIDGE NEUROSCIENCE, INC. | 2004-06-29 | — | — | US | disclosed |
| US-20030069274-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | WYETH | 2003-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209222-A1 | Pharmaceutically active compounds and methods of use | ACHE, NLN, PARK7 | HPGD 130/4885ALDH1A1 434/4885POLB 1603/4885 |
| US-20030069274-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | ACHE, NLN, PARK7 | HPGD 130/4885ALDH1A1 434/4885POLB 1603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.