SCHEMBL4874715

SCHEMBL4874715

Cc1nc(C)c(-c2ccc3cc(-c4c(-c5ccccc5)c5sc(C(=O)O)cc5n4CC(=O)N4CCC(N5CCOCC5)CC4)ccc3n2)s1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.38
CREBBP Q92793 1/20 0.38
CBX7 O95931 1/20 0.38
CDYL2 Q8N8U2 1/20 0.38
CDYL Q9Y232 1/20 0.38
CDY1; CDY1B Q9Y6F8 1/20 0.38
ACHE P22303 1/20 0.38
GRIN2B Q13224 1/20 0.36
GSK3B P49841 1/20 0.36
DYRK1A Q13627 1/20 0.36
POLB P06746 2/20 0.35
GAA P10253 1/20 0.35
TSHR P16473 1/20 0.35
KCNH2 Q12809 3/20 0.35
HRH3 Q9Y5N1 2/20 0.35
ACACB O00763 1/20 0.34
ACACA Q13085 1/20 0.34
TP53 P04637 1/20 0.34
SMO Q99835 1/20 0.34
KDM4E B2RXH2 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4877286 0.94 POLB (0.41) CBX7CDYL2CDYLCDY1; CDY1BACHE
SCHEMBL3931413 0.93 BRD4 (0.42) BRD4CREBBPGRIN2BPOLBGAA
SCHEMBL4868321 0.90 KCNH2 (0.38) BRD4CREBBPGRIN2BKCNH2HRH3
SCHEMBL4868434 0.90 CBX7 (0.42) BRD4CREBBPCBX7CDYL2CDYL
SCHEMBL4877137 0.90 CBX7 (0.39) BRD4CREBBPCBX7CDYL2CDYL
SCHEMBL4874701 0.89 TP53 (0.36) BRD4CREBBPCBX7CDYL2CDYL
SCHEMBL4876223 0.89 GRIN2B (0.39) BRD4CREBBPGRIN2BGAATSHR
SCHEMBL4876347 0.89 GRIN2B (0.39) BRD4CREBBPGRIN2BGAATSHR
SCHEMBL3934917 0.88 GRIN2B (0.38) GRIN2BGAATSHRKCNH2HRH3
SCHEMBL4877781 0.88 ACHE (0.43) BRD4CREBBPCBX7CDYL2CDYL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080051384-A1 ANTIVIRAL AGENTS GENELABS TECHNOLOGIES, INC. 2008-02-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080051384-A1 ANTIVIRAL AGENTS EIF2AK2, MAVS, ZC3HAV1 BRD4 3577/4885CREBBP 2805/4885CBX7 2500/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.