Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 14/20 | 0.62 |
| ▸ | PPARA | Q07869 | 14/20 | 0.62 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4874817 | 1.00 | PPARG (0.62) | PPARGPPARAPTPN1SLC6A9SLC6A2 | |
| SCHEMBL4874822 | 1.00 | PPARG (0.62) | PPARGPPARAPTPN1SLC6A9SLC6A2 | |
| SCHEMBL1343050 | 0.86 | PPARG (0.59) | PPARGPPARAPTPN1SLC6A9SLC6A2 | |
| SCHEMBL9797759 | 0.85 | PPARG (0.66) | PPARGPPARASLC6A9 | |
| SCHEMBL5601391 | 0.83 | PPARG (0.47) | PPARGPPARAPTPN1SLC6A9 | |
| Hydrochloric Acid SCHEMBL9811662 | 0.83 | PPARG (0.64) | PPARGPPARASLC6A9 | |
| SCHEMBL585488 | 0.81 | PPARG (0.53) | PPARGPPARA | |
| SCHEMBL16571566 | 0.80 | PPARG (0.67) | PPARGPPARAPTPN1SLC6A9 | |
| SCHEMBL9062048 | 0.79 | PPARG (0.61) | PPARGPPARA | |
| SCHEMBL9062031 | 0.78 | PPARG (0.49) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080015253-A1 | Pentenoic Acid Derivatives, Processes For The Preparation Thereof, Pharmaceutical Compositions Comprising Them, And Therapeutic Applications Thereof | MERCK PATENT GMBH (DE) | 2008-01-17 | — | — | US | claimed |
| JP-2007536289-A | — | — | 2007-12-13 | — | — | JP | claimed |
| EP-1742903-B1 | PENTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF | MERCK PATENT GMBH (DE) | 2007-08-22 | — | — | EP | claimed |
| EP-1742903-A1 | PENTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF | MERCK PATENT GmbH (DE) | 2007-01-17 | — | — | EP | claimed |
| WO-2005105723-A1 | PENTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF | MERCK PATENT GMBH (DE) | 2005-11-10 | — | — | WO | claimed |
| US-7465752-B2 | Pentenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic applications thereof | MERCK PATENT GMBH (DE) | 2008-12-16 | — | — | US | disclosed |
| US-20080015253-A1 | Pentenoic Acid Derivatives, Processes For The Preparation Thereof, Pharmaceutical Compositions Comprising Them, And Therapeutic Applications Thereof | MERCK PATENT GMBH (DE) | 2008-01-17 | — | — | US | disclosed |
| EP-1742903-B1 | PENTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF | MERCK PATENT GMBH (DE) | 2007-08-22 | — | — | EP | disclosed |
| EP-1742903-A1 | PENTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF | MERCK PATENT GmbH (DE) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005105723-A1 | PENTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF | MERCK PATENT GMBH (DE) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015253-A1 | Pentenoic Acid Derivatives, Processes For The Preparation Thereof, Pharmaceutical Compositions Comprising Them, And Therapeutic Applications Thereof | ALOX5, GPR119, ALOX15B | PPARG 110/4885PPARA 62/4885PTPN1 3394/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.