SCHEMBL4875473

SCHEMBL4875473

O=C(COCc1ccccc1)NC1CCCC1

nearest known ligand 0.65

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 2/20 0.65
ALDH1A1 P00352 5/20 0.61
KMT2A Q03164 6/20 0.61
MEN1 O00255 5/20 0.61
ATM Q13315 1/20 0.61
SMN1; SMN2 Q16637 4/20 0.58
TSHR P16473 1/20 0.58
L3MBTL1 Q9Y468 1/20 0.56
EPHX1 P07099 1/20 0.56
LMNA P02545 3/20 0.55
HPGD P15428 1/20 0.55
HTT P42858 1/20 0.55
SGMS2 Q8NHU3 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17740993 0.92 EPHX2 (0.62) EPHX2ALDH1A1KMT2AMEN1ATM
SCHEMBL5106611 0.84 L3MBTL1 (0.81) L3MBTL1
SCHEMBL6381661 0.83 ATM (0.50) EPHX2ALDH1A1ATMSMN1; SMN2TSHR
SCHEMBL6381668 0.83 ATM (0.50) EPHX2ALDH1A1ATMSMN1; SMN2TSHR
SCHEMBL6381663 0.83 ATM (0.50) EPHX2ALDH1A1ATMSMN1; SMN2TSHR
SCHEMBL25893846 0.82 KMT2A (0.73) EPHX2ALDH1A1KMT2AMEN1SMN1; SMN2
SCHEMBL5713019 0.81 ALDH1A1 (0.68) EPHX2ALDH1A1KMT2AMEN1EPHX1
SCHEMBL2753089 0.80 EPHX2 (0.96) EPHX2ALDH1A1KMT2AMEN1EPHX1
SCHEMBL14520880 0.79 ATM (0.49) EPHX2ALDH1A1KMT2AMEN1ATM
Hydrochloric Acid SCHEMBL5047929 0.79 EPHX2 (0.93) EPHX2ALDH1A1KMT2AMEN1EPHX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080166310-A1 Administration of 2-oxyacetamide compounds for promoting and/or inducing and/or stimulating the pigmentation of keratin materials and/or for limiting the depigmentation and/or bleaching thereof L'OREAL (FR) 2008-07-10 US disclosed
US-20080166310-A1 Administration of 2-oxyacetamide compounds for promoting and/or inducing and/or stimulating the pigmentation of keratin materials and/or for limiting the depigmentation and/or bleaching thereof L'OREAL (FR) 2008-07-10 US disclosed
US-20080166310-A1 Administration of 2-oxyacetamide compounds for promoting and/or inducing and/or stimulating the pigmentation of keratin materials and/or for limiting the depigmentation and/or bleaching thereof L'OREAL (FR) 2008-07-10 US disclosed
US-20070092467-A1 Oxyacetamide compounds useful for stimulating or inducing the growth and/or retarding the loss of keratin fibers L'OREAL (FR) 2007-04-26 US disclosed
US-20070092467-A1 Oxyacetamide compounds useful for stimulating or inducing the growth and/or retarding the loss of keratin fibers L'OREAL (FR) 2007-04-26 US disclosed
US-20070092467-A1 Oxyacetamide compounds useful for stimulating or inducing the growth and/or retarding the loss of keratin fibers L'OREAL (FR) 2007-04-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070092467-A1 Oxyacetamide compounds useful for stimulating or inducing the growth and/or retarding the loss of keratin fibers HPGD, KRT18, PTGS1 EPHX2 784/4885ALDH1A1 208/4885KMT2A 2509/4885
US-20080166310-A1 Administration of 2-oxyacetamide compounds for promoting and/or inducing and/or stimulating the pigmentation of keratin materials and/or for limiting the depigmentation and/or bleaching thereof KRT18, TYR, CRYAA EPHX2 1447/4885ALDH1A1 539/4885KMT2A 82/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.