Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ketoprofen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 0.68 |
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.68 |
| ▸ | MAPT | P10636 | 5/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.68 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.68 |
| ▸ | RECQL | P46063 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.68 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.68 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.68 |
| ▸ | THPO | P40225 | 1/20 | 0.68 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ketoprofen SCHEMBL28602451 | 0.83 | PTGS1 (0.93) | MAPTALDH1A1SMN1; SMN2PTGS1PTGS2 | |
| R-Ketoprofen SCHEMBL29353694 | 0.83 | PTGS1 (1.00) | MAPTALDH1A1SMN1; SMN2PTGS1PTGS2 | |
| R-Ketoprofen SCHEMBL195303 | 0.83 | PTGS1 (1.00) | MAPTALDH1A1SMN1; SMN2PTGS1PTGS2 | |
| Ketoprofen SCHEMBL8577572 | 0.83 | PTGS1 (1.00) | MAPTALDH1A1SMN1; SMN2PTGS1PTGS2 | |
| Ketoprofen SCHEMBL679920 | 0.83 | PTGS1 (1.00) | MAPTALDH1A1SMN1; SMN2PTGS1PTGS2 | |
| Dexketoprofen SCHEMBL29396875 | 0.83 | PTGS1 (1.00) | MAPTALDH1A1SMN1; SMN2PTGS1PTGS2 | |
| Ketoprofen SCHEMBL3843886 | 0.83 | PTGS1 (1.00) | MAPTALDH1A1SMN1; SMN2PTGS1PTGS2 | |
| Ketoprofen SCHEMBL16757741 | 0.83 | PTGS1 (1.00) | MAPTALDH1A1SMN1; SMN2PTGS1PTGS2 | |
| Ketoprofen SCHEMBL8754790 | 0.83 | PTGS1 (1.00) | MAPTALDH1A1SMN1; SMN2PTGS1PTGS2 | |
| Dexketoprofen SCHEMBL66987 | 0.83 | PTGS1 (1.00) | MAPTALDH1A1SMN1; SMN2PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080132751-A1 | by the administration of analgesics that are encapsulated in diacylglycerol-polyethyleneglycol liposomes and delivered sublingually as aerosols | BETAZONE LABORATORIES, INC. | 2008-06-05 | — | — | US | claimed |
| US-20080132751-A1 | by the administration of analgesics that are encapsulated in diacylglycerol-polyethyleneglycol liposomes and delivered sublingually as aerosols | BETAZONE LABORATORIES, INC. | 2008-06-05 | — | — | US | disclosed |