Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11559664 | 0.71 | MAPT (0.46) | RXFP1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL7989249 | 0.70 | MAPT (0.46) | RXFP1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL568818 | 0.70 | TSHR (0.47) | RXFP1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL623383 | 0.69 | MAPT (0.52) | RXFP1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL976216 | 0.69 | HDAC6 (0.55) | RXFP1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL3309431 | 0.69 | HDAC6 (0.49) | RXFP1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL9737791 | 0.68 | TSHR (0.42) | RXFP1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL10656068 | 0.68 | HSP90AA1 (0.52) | RXFP1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL7975250 | 0.67 | MAPT (0.42) | RXFP1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL1713222 | 0.67 | TSHR (0.57) | MAPTKDM4EGAASMN1; SMN2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080058368-A1 | 4,5,6,7-Tetrahydro-[1,2]Dithiolo[4,3-C] Pyridine-3-Thione Compounds | PROTHERAPEUTICS INC. (KR) | 2008-03-06 | — | — | US | claimed |
| WO-2006080745-A1 | NEW 4,5,6,7-TETRAHYDRO-[1,2]DITHIOLO[4,3-C]PYRIDINE-3-THIONE COMPOUNDS | CJ CORPORATION (KR) | 2006-08-03 | — | — | WO | claimed |
| US-7435819-B2 | 4,5,6,7-tetrahydro-[1,2]dithiolo[4,3-C] pyridine-3-thione compounds | CJ CHEILJEDANG CORP. (KR) | 2008-10-14 | — | — | US | disclosed |
| US-20080058368-A1 | 4,5,6,7-Tetrahydro-[1,2]Dithiolo[4,3-C] Pyridine-3-Thione Compounds | PROTHERAPEUTICS INC. (KR) | 2008-03-06 | — | — | US | disclosed |
| WO-2006080745-A1 | NEW 4,5,6,7-TETRAHYDRO-[1,2]DITHIOLO[4,3-C]PYRIDINE-3-THIONE COMPOUNDS | CJ CORPORATION (KR) | 2006-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058368-A1 | 4,5,6,7-Tetrahydro-[1,2]Dithiolo[4,3-C] Pyridine-3-Thione Compounds | RPS6KA1, RPS6KA5, RPS6KA3 | RXFP1 2426/4885MAPT 4014/4885KDM4E 2574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.