Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.53 |
| ▸ | KDM6B | O15054 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.43 |
| ▸ | ERN1 | O75460 | 5/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14870835 | 1.00 | CDK1 (0.53) | CDK1KDM6BALOX15KDM4ERECQL | |
| SCHEMBL14742604 | 0.83 | CDK1 (0.59) | CDK1ALOX15KDM4ERECQLHIF1A | |
| SCHEMBL17211513 | 0.82 | KDM6B (0.66) | KDM6BALOX15KDM4ERECQLHIF1A | |
| SCHEMBL1755353 | 0.82 | KDM6B (0.66) | KDM6BALOX15KDM4ERECQLHIF1A | |
| SCHEMBL17414653 | 0.82 | KDM6B (0.66) | KDM6BALOX15KDM4ERECQLHIF1A | |
| SCHEMBL30388652 | 0.82 | KDM6B (0.66) | KDM6BALOX15KDM4ERECQLHIF1A | |
| SCHEMBL11674803 | 0.81 | SLC7A5 (0.69) | CDK1KDM6BALOX15KDM4ERECQL | |
| SCHEMBL5833111 | 0.81 | SLC7A5 (0.69) | CDK1KDM6BALOX15KDM4ERECQL | |
| SCHEMBL29733305 | 0.81 | SLC7A5 (0.69) | CDK1KDM6BALOX15KDM4ERECQL | |
| SCHEMBL16275203 | 0.81 | CDK1 (0.49) | CDK1KDM6BALOX15KDM4ERECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120283287-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | QIAN XIANGPING (US) | 2012-11-08 | — | — | US | disclosed |
| US-20080242644-A1 | Factor Viia Inhibitor | PHARMACYCLICS, INC. (US) | 2008-10-02 | — | — | US | disclosed |
| EP-1751114-A2 | FACTOR VIIA INHIBITOR | PHARMACYCLICS, INC. (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005121102-A2 | FACTOR VIIA INHIBITOR | PHARMACYCLICS, INC. (US) | 2005-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242644-A1 | Factor Viia Inhibitor | F7, F9, F5 | CDK1 1336/4885KDM6B 796/4885ALOX15 2594/4885 |
| US-20120283287-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | KIF5B, KIF2C, PLK1 | CDK1 55/4885KDM6B 2420/4885ALOX15 4698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.