SCHEMBL4876599

SCHEMBL4876599

O=C(O)c1cc2c(s1)c(-c1ccccc1)c(-c1ccc3nc(-c4c(F)cccc4F)ccc3c1)n2CC(=O)N1CCSC1

nearest known ligand 0.34

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 7/20 0.33
DPP7 Q9UHL4 3/20 0.33
MGLL Q99685 1/20 0.32
MAPT P10636 1/20 0.30
RXFP1 Q9HBX9 1/20 0.30
AKR1A1 P14550 1/20 0.30
AKR1B1 P15121 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4875677 0.88 GRIN2B (0.34) MGLLMAPTRXFP1
SCHEMBL4879016 0.88 KMT2A (0.36) DPP4
SCHEMBL4876592 0.88 DPP4 (0.32) DPP4DPP7
SCHEMBL4872630 0.87 GRIN2B (0.33) DPP4MAPT
SCHEMBL4876586 0.86 KCNH2 (0.34) DPP4
SCHEMBL4876271 0.84 HPGD (0.31) MAPT
SCHEMBL4877153 0.84 GRIN2B (0.40) MAPT
SCHEMBL4875207 0.83 GRIN2B (0.33) MAPTRXFP1
SCHEMBL4877469 0.83 GRIN2B (0.35)
SCHEMBL3928018 0.82 GRIN2B (0.42)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080051384-A1 ANTIVIRAL AGENTS GENELABS TECHNOLOGIES, INC. 2008-02-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080051384-A1 ANTIVIRAL AGENTS EIF2AK2, MAVS, ZC3HAV1 DPP4 191/4885DPP7 303/4885MGLL 1522/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.