SCHEMBL4877983

SCHEMBL4877983

Cc1cccc(C(C)c2nccn2C(=O)OCc2ccc3ccccc3c2)c1C

nearest known ligand 0.37

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 2/20 0.37
GSK3A P49840 2/20 0.36
MAPK10 P53779 2/20 0.36
RIOK2 Q9BVS4 2/20 0.36
MAPK8 P45983 1/20 0.36
HIPK1 Q86Z02 1/20 0.36
SNRK Q9NRH2 1/20 0.36
MAOB P27338 1/20 0.36
TACR1 P25103 1/20 0.36
CES2 O00748 1/20 0.35
ALOX5 P09917 3/20 0.35
CYP17A1 P05093 1/20 0.34
PTGDR2 Q9Y5Y4 1/20 0.34
SLC1A3 P43003 1/20 0.34
SLC1A2 P43004 1/20 0.34
SLC1A1 P43005 1/20 0.34
CACNA1B Q00975 1/20 0.34
CASR P41180 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL697622 1.00 FFAR1 (0.37) FFAR1GSK3AMAPK10RIOK2MAPK8
SCHEMBL3531096 0.91 CES2 (0.38) GSK3AMAPK10RIOK2MAPK8HIPK1
SCHEMBL697860 0.89 FFAR1 (0.35) FFAR1RIOK2
SCHEMBL697760 0.88 L3MBTL1 (0.38) FFAR1
SCHEMBL697165 0.87 GRIN2B (0.42) FFAR1MAOB
SCHEMBL703335 0.87 GRIN2B (0.42) FFAR1
SCHEMBL698126 0.87 GRIN2B (0.41) MAOB
SCHEMBL712178 0.87 FFAR1 (0.41) FFAR1
SCHEMBL708924 0.86 FFAR1 (0.38) FFAR1
SCHEMBL699122 0.86 FFAR1 (0.41) FFAR1MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1981853-A1 SUBSTITUTED IMIDAZOLES AND THEIR USE AS PESTICIDES Pfizer Limited (GB) 2008-10-22 EP disclosed
WO-2007083207-A1 SUBSTITUTED IMIDAZOLES AND THEIR USE AS PESTICIDES PFIZER LIMITED (GB) 2007-07-26 WO disclosed