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SCHEMBL698126

SCHEMBL698126

Cc1ccc(COC(=O)n2ccnc2[C@@H](C)c2cccc(C)c2C)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GRIN2B Q13224 5/20 0.41
▸ P2RX4 Q99571 1/20 0.38
▸ MMP2 P08253 2/20 0.35
▸ MMP12 P39900 2/20 0.35
▸ MMP1 P03956 1/20 0.35
▸ MMP9 P14780 1/20 0.35
▸ LMNA P02545 2/20 0.34
▸ MAPT P10636 2/20 0.34
▸ L3MBTL1 Q9Y468 2/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ TRPV1 Q8NER1 1/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ MAOB P27338 2/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ ALDH1A1 P00352 1/20 0.33
▸ NPY1R P25929 1/20 0.33
▸ ADORA2A P29274 1/20 0.33
▸ RECQL P46063 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL697760 0.93 L3MBTL1 (0.38) GRIN2BP2RX4LMNAMAPTL3MBTL1
SCHEMBL696660 0.92 GRIN2B (0.38) GRIN2BMMP2MMP12MMP1MMP9
SCHEMBL698919 0.92 L3MBTL1 (0.38) GRIN2BMMP1LMNAMAPTL3MBTL1
SCHEMBL703335 0.92 GRIN2B (0.42) GRIN2BLMNAMAPTL3MBTL1RAB9A
SCHEMBL696991 0.92 L3MBTL1 (0.40) GRIN2BP2RX4MMP2MMP12MMP1
SCHEMBL696627 0.91 GRIN2B (0.40) GRIN2BP2RX4MMP2MMP12MMP1
SCHEMBL704575 0.91 FFAR1 (0.38) L3MBTL1RAB9ANAAA
SCHEMBL3533515 0.91 TP53 (0.40) LMNAMAPTL3MBTL1RAB9AMEN1
SCHEMBL697782 0.91 GRIN2B (0.35) GRIN2BLMNAMEN1KMT2AALDH1A1
SCHEMBL699044 0.90 FNTA (0.41) LMNARAB9ASMN1; SMN2MAOBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2423199-A1 Substituted imidazoles and their use as pesticides Pfizer Limited (GB) 2012-02-29 — — EP disclosed
US-7825149-B2 Substituted imidazoles PFIZER LIMITED (GB) 2010-11-02 — — US disclosed
US-20090312326-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2009-12-17 — — US disclosed
US-7592362-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-09-22 — — US disclosed
US-7547718-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-06-16 — — US disclosed
US-7544706-B2 Substituted imidazoles PFIZER LIMITED (GB) 2009-06-09 — — US disclosed
US-20080125473-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2008-05-29 — — US disclosed
US-20080119536-A1 SUBSTITUTED IMIDAZOLES PFIZER LIMITED (GB) 2008-05-22 — — US disclosed
US-20070167506-A1 SUBSTITUTED IMIDAZOLES PFIZER INC. (US) 2007-07-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080125473-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 GRIN2B 3622/4885P2RX4 710/4885MMP2 3529/4885
US-20090312326-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 GRIN2B 3622/4885P2RX4 710/4885MMP2 3529/4885
US-20070167506-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 GRIN2B 3622/4885P2RX4 710/4885MMP2 3529/4885
US-20080119536-A1 SUBSTITUTED IMIDAZOLES ABL1, TYR, CYP3A4 GRIN2B 3622/4885P2RX4 710/4885MMP2 3529/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.