Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 14/20 | 0.55 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4885535 | 0.87 | CRHR1 (0.52) | CRHR1SCN9ARUNX1 | |
| SCHEMBL4882896 | 0.87 | CRHR1 (0.60) | CRHR1SCN9A | |
| SCHEMBL4885196 | 0.86 | CRHR1 (0.60) | CRHR1SCN9ARUNX1 | |
| SCHEMBL5438230 | 0.85 | CRHR1 (0.64) | CRHR1SCN9A | |
| SCHEMBL4878160 | 0.84 | CRHR1 (0.53) | CRHR1SCN9ARUNX1CTSAGRIN2B | |
| SCHEMBL6604201 | 0.83 | CRHR1 (0.49) | CRHR1SCN9ARUNX1 | |
| SCHEMBL5439514 | 0.82 | CRHR1 (0.53) | CRHR1SCN9ARUNX1ADORA3CTSA | |
| SCHEMBL5441669 | 0.80 | CRHR1 (0.65) | CRHR1SCN9A | |
| SCHEMBL5435133 | 0.80 | CRHR1 (0.60) | CRHR1SCN9A | |
| SCHEMBL5464166 | 0.80 | CRHR1 (0.60) | CRHR1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080107608-A1 | 5-Substituted-2-Arylpyridines | GE PING | 2008-05-08 | — | — | US | disclosed |
| US-20080107608-A1 | 5-Substituted-2-Arylpyridines | GE PING | 2008-05-08 | — | — | US | disclosed |
| US-20080107608-A1 | 5-Substituted-2-Arylpyridines | GE PING | 2008-05-08 | — | — | US | disclosed |
| US-7223778-B2 | 5-substituted-2-arylpyridines | NEUROGEN CORPORATION (US) | 2007-05-29 | — | — | US | disclosed |
| US-7223778-B2 | 5-substituted-2-arylpyridines | NEUROGEN CORPORATION (US) | 2007-05-29 | — | — | US | disclosed |
| US-7223778-B2 | 5-substituted-2-arylpyridines | NEUROGEN CORPORATION (US) | 2007-05-29 | — | — | US | disclosed |
| US-20030152520-A1 | 5-Substituted-2-arylpyridines | NEUROGEN CORPORATION | 2003-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030152520-A1 | 5-Substituted-2-arylpyridines | HTR5A, CRHR2, HTR2C | CRHR1 5/4885SCN9A 3544/4885RUNX1 1770/4885 |
| US-20080107608-A1 | 5-Substituted-2-Arylpyridines | CRHR2, CRHR1, HTR2C | CRHR1 2/4885SCN9A 3903/4885RUNX1 2949/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.