Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 10/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.36 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602770 | 0.87 | CRHR1 (0.54) | CRHR1SCN9ANR1I2RUNX1GRM7 | |
| SCHEMBL6607143 | 0.86 | CRHR1 (0.54) | CRHR1SCN9ANR1I2RUNX1FFAR1 | |
| SCHEMBL6603304 | 0.86 | CRHR1 (0.46) | CRHR1SCN9ANR1I2RUNX1FFAR1 | |
| SCHEMBL6204110 | 0.85 | CRHR1 (0.58) | CRHR1SCN9ANR1I2RUNX1GRM7 | |
| SCHEMBL6203296 | 0.85 | CRHR1 (0.57) | CRHR1SCN9ANR1I2RUNX1 | |
| SCHEMBL6202563 | 0.85 | CRHR1 (0.57) | CRHR1SCN9ANR1I2RUNX1 | |
| SCHEMBL4878173 | 0.83 | CRHR1 (0.55) | CRHR1SCN9ARUNX1 | |
| SCHEMBL6203243 | 0.83 | CRHR1 (0.48) | CRHR1SCN9ANR1I2RUNX1GRM7 | |
| SCHEMBL6202901 | 0.82 | CRHR1 (0.47) | CRHR1SCN9ANR1I2RUNX1GRM7 | |
| SCHEMBL6204821 | 0.81 | CRHR1 (0.58) | CRHR1SCN9ARUNX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392302-A1 | 5-SUBSTITUTED-2-ARYLPYRIDINES AS CRF1 MODULATORS | NEUROGEN CORPORATION (US) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002096421-A1 | 5-SUBSTITUTED-2-ARYLPYRIDINES AS CRF1 MODULATORS | NEUROGEN CORPORATION (US) | 2002-12-05 | — | — | WO | disclosed |