SCHEMBL487844

SCHEMBL487844

Nc1ccccc1/C=N/Nc1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 12/20 0.62
MEN1 O00255 10/20 0.62
KMT2A Q03164 10/20 0.62
GAA P10253 10/20 0.62
ALDH1A1 P00352 7/20 0.62
HPGD P15428 6/20 0.62
GFER P55789 1/20 0.62
NOX1 Q9Y5S8 2/20 0.57
SENP7 Q9BQF6 3/20 0.50
RAB9A P51151 7/20 0.49
LMNA P02545 3/20 0.49
SMN1; SMN2 Q16637 5/20 0.47
KDM4E B2RXH2 5/20 0.47
MAPK1 P28482 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
NPC1 O15118 5/20 0.44
ALOX12 P18054 2/20 0.42
CASP3 P42574 2/20 0.42
SENP8 Q96LD8 1/20 0.42
SENP6 Q9GZR1 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL487843 1.00 MAPT (0.62) MAPTMEN1KMT2AGAAALDH1A1
Pyrrole SCHEMBL1359313 0.90 GAA (0.53) MAPTMEN1KMT2AGAAALDH1A1
SCHEMBL8316277 0.86 MAPT (0.56) MAPTMEN1KMT2AGAAALDH1A1
SCHEMBL10910531 0.83 MEN1 (0.46) MAPTMEN1KMT2AGAAALDH1A1
SCHEMBL3065879 0.77 MAPT (0.62) MAPTMEN1KMT2AGAAALDH1A1
SCHEMBL734790 0.77 KMT2A (1.00) MAPTMEN1KMT2AGAAALDH1A1
SCHEMBL3065881 0.77 MAPT (0.62) MAPTMEN1KMT2AGAAALDH1A1
SCHEMBL6714200 0.77 MAPT (0.62) MAPTMEN1KMT2AGAAALDH1A1
SCHEMBL734791 0.77 KMT2A (1.00) MAPTMEN1KMT2AGAAALDH1A1
SCHEMBL6714202 0.77 MAPT (0.62) MAPTMEN1KMT2AGAAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 150 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2459227-B1 Prodrugs containing an aromatic amine connected by an amide bond to a carrier ASCENDIS PHARMA AS (DK) 2021-03-17 EP claimed
US-20230251257-A1 SUBSTRATE FOR IMMOBILIZING SUBSTANCE, AND USE THEREOF R-NANOBIO CO. LTD. (JP) 2023-08-10 US disclosed
WO-2023122075-A1 COMPOSITIONS COMPRISING STEROL-AMINO-PHOSPHATE COMPOUNDS AND METHODS OF MAKING AND USE THEREOF OHIO STATE INNOVATION FOUNDATION (US) 2023-06-29 WO disclosed
WO-2023117590-A1 SOLUTION ELECTROSPUN FIBERS, COMPOSITIONS COMPRISING THE SAME AND A PROCESS OF MANUFACTURING THEREOF UNIVERSITEIT GENT (BE) 2023-06-29 WO disclosed
CN-115917322-A Substance-immobilizing substrate and use thereof 国立研究开发法人理化学研究所 2023-04-04 CN disclosed
EP-4151712-A1 SUBSTRATE FOR IMMOBILIZING SUBSTANCE, AND USE THEREOF RIKEN (JP) 2023-03-22 EP disclosed
CN-115808843-A Curable resin composition, cured film thereof, and display device 住友化学株式会社 2023-03-17 CN disclosed
CN-115089637-A Application of evodia rutaecarpa alcohol extract and/or rutaecarpine in preparation of novel coronavirus resistant medicines 香港科技大学 2022-09-23 CN disclosed
CN-114703148-A Phage STP55 capable of simultaneously cracking salmonella and escherichia coli and application 华中农业大学 2022-07-05 CN disclosed
EP-3490981-A1 SUBSTITUTED HALOGEN(THIO)ACYL COMPOUNDS Bayer CropScience Aktiengesellschaft (DE) 2019-06-05 EP disclosed
EP-0664119-B1 Tape transdermal use easily detachable from the skin NITTO DENKO CORP (JP) 2001-08-29 EP disclosed
US-6117670-A NUCLEIC ACID SEQUENCE THAT CODES AN ENZYMATIC PROTEIN WHICH PREVENTS INFECTION AND PROPAGATION OF PHYTOPATHOGENS IN PLANTS; FOR BIOLOGICAL PEST CONTROL; BACTERICIDES NOVARTIS FINANCE CORPORATION (US) 2000-09-12 US disclosed
US-5814032-A DRUG DELIVERY WITH TAPE FOR TRANSDERMAL DELIVERY AND MULTILAYER BANDAGES NITTO DENKO CORPORATION (JP) 1998-09-29 US disclosed
EP-0664119-A2 Tape transdermal use easily detachable from the skin NITTO DENKO CORPORATION (JP) 1995-07-26 EP disclosed
US-5120735-A Synergistic mixture of miconazole, ketoconazole or fluconazole and N-4-tertbutylbenzyl-N-methyl-1-naphthalenemethylamine KAKEN PHARMACEUTICAL CO., LTD. (JP) 1992-06-09 US disclosed
WO-1988001516-A1 TRANSDERMAL THERAPEUTIC SYSTEM, ITS USE AND PRODUCTION PROCESS LOHMANN GMBH & CO. KG. (DE) 1988-03-10 WO disclosed
EP-0065884-B1 URETHRAL CATHETER CAPABLE OF PREVENTING URINARY TRACT INFECTION AND PROCESS FOR PRODUCING THE SAME UNITIKA LTD. (JP) 1986-08-20 EP disclosed
US-4298395-A HALOGENATED PYRIMIDINE ACTIVATOR FOR BINDING LIGANDS BAYER AKTIENGESELLSCHAFT (DE) 1981-11-03 US disclosed
US-4195128-A LIGAND BOUND TO CARRIER THROUGH PYRIMIDINE DERIVATIVE BAYER AKTIENGESELLSCHAFT (DE) 1980-03-25 US disclosed
US-4144128-A Polymeric carrier bound ligands BAYER AKTIENGESELLSCHAFT (DE) 1979-03-13 US disclosed