Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4462461 | 0.87 | KDM4E (0.40) | ALDH1A1PTPN1KMT2AKDM4EHTT | |
| SCHEMBL4883198 | 0.86 | HDAC3 (0.37) | ALDH1A1PTPN1KMT2AKDM4ENPC1 | |
| SCHEMBL4697608 | 0.75 | CTSB (0.31) | — | |
| SCHEMBL4473238 | 0.74 | KDM4E (0.43) | ALDH1A1PTPN1KMT2AKDM4ENPC1 | |
| SCHEMBL4698253 | 0.73 | — | — | |
| SCHEMBL4463487 | 0.71 | KDM4E (0.30) | KDM4E | |
| SCHEMBL4463485 | 0.71 | KDM4E (0.30) | KDM4E | |
| SCHEMBL4468166 | 0.69 | KDM4E (0.32) | ALDH1A1KMT2AKDM4EHPGD | |
| SCHEMBL4468728 | 0.69 | KDM4E (0.30) | ALDH1A1KDM4EHPGD | |
| SCHEMBL4471135 | 0.69 | KDM4E (0.30) | ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080207588-A1 | Spiro-Heterocyclic Chromans, Thiochromans and Dihydroquinolines | CHU DANIEL T W | 2008-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207588-A1 | Spiro-Heterocyclic Chromans, Thiochromans and Dihydroquinolines | CBR3, CBR1, DHRS9 | ALDH1A1 354/4885PTPN1 995/4885KMT2A 3253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.