⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4468756 | 0.87 | MEN1 (0.34) | — | |
| SCHEMBL4465317 | 0.87 | MEN1 (0.34) | — | |
| SCHEMBL4486240 | 0.87 | MEN1 (0.34) | — | |
| SCHEMBL4702477 | 0.84 | HSP90AB1 (0.32) | — | |
| SCHEMBL5270027 | 0.83 | MEN1 (0.38) | — | |
| SCHEMBL4702551 | 0.81 | CTSD (0.31) | — | |
| SCHEMBL4699973 | 0.79 | — | — | |
| SCHEMBL4697608 | 0.74 | CTSB (0.31) | — | |
| SCHEMBL4880124 | 0.73 | ALDH1A1 (0.36) | — | |
| SCHEMBL4459375 | 0.72 | FDPS (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856079-A4 | SPIRO-HETEROCYCLIC CHROMANS, THIOCHROMANS AND DIHYDROQUINOLINES | GALILEO PHARMACEUTICALS INC (US) | 2008-12-31 | — | — | EP | disclosed |
| US-20080207588-A1 | Spiro-Heterocyclic Chromans, Thiochromans and Dihydroquinolines | CHU DANIEL T W | 2008-08-28 | — | — | US | disclosed |
| EP-1856079-A1 | SPIRO-HETEROCYCLIC CHROMANS, THIOCHROMANS AND DIHYDROQUINOLINES | Galileo Pharmaceuticals, Inc. (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006093548-A1 | SPIRO-HETEROCYCLIC CHROMANS, THIOCHROMANS AND DIHYDROQUINOLINES | GALILEO PHARMACEUTICALS, INC. (US) | 2006-09-08 | — | — | WO | disclosed |