Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.51 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5527596 | 0.83 | OPRM1 (0.48) | HCRTR1HCRTR2HDAC8OPRM1OPRK1 | |
| SCHEMBL12126117 | 0.78 | PRCP (0.55) | OPRM1OPRK1 | |
| SCHEMBL29159488 | 0.77 | OPRM1 (0.54) | HDAC8OPRM1OPRK1HDAC3HDAC1 | |
| SCHEMBL12124978 | 0.74 | PRCP (0.56) | OPRM1OPRK1 | |
| SCHEMBL11784786 | 0.73 | MTNR1B (0.48) | OPRM1OPRK1MEN1KMT2A | |
| SCHEMBL8560553 | 0.72 | OPRM1 (0.49) | HDAC8OPRM1OPRK1HDAC3HDAC1 | |
| SCHEMBL14417432 | 0.71 | OPRM1 (0.48) | OPRM1OPRK1 | |
| Hydrochloric Acid SCHEMBL10640540 | 0.70 | OPRM1 (0.49) | HDAC8OPRM1OPRK1MAPTMEN1 | |
| SCHEMBL9599601 | 0.69 | OPRM1 (0.51) | HDAC8OPRM1OPRK1HDAC3HDAC1 | |
| SCHEMBL12125928 | 0.69 | PRCP (0.59) | OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322309-B1 | HIGH AFFINITY SMALL MOLECULE C5A RECEPTOR MODULATORS | NEUROGEN CORP (US) | 2008-08-13 | — | — | EP | disclosed |