Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | ACE | P12821 | 4/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.50 |
| ▸ | PRCP | P42785 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4239790 | 0.85 | PRCP (0.60) | ACEHDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL3609218 | 0.79 | ACE (0.70) | ACEHDAC3HDAC1 | |
| SCHEMBL3609137 | 0.78 | ACE (0.52) | ACEHDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL22525235 | 0.77 | PRCP (0.57) | OPRM1OPRK1ACEPRCP | |
| SCHEMBL2088793 | 0.77 | PRCP (0.57) | OPRM1OPRK1ACEPRCP | |
| SCHEMBL9387516 | 0.77 | OPRM1 (0.57) | OPRM1OPRK1HDAC8HDAC3HDAC1 | |
| SCHEMBL28851671 | 0.77 | CYP2D6 (0.47) | OPRM1OPRK1HDAC8HDAC3HDAC1 | |
| SCHEMBL29159488 | 0.77 | OPRM1 (0.54) | OPRM1OPRK1HDAC8HDAC3HDAC1 | |
| SCHEMBL3612877 | 0.76 | OPRM1 (0.42) | OPRM1OPRK1HDAC8HDAC3HDAC1 | |
| SCHEMBL3608890 | 0.76 | OPRM1 (0.44) | OPRM1OPRK1HDAC8HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5238935-A | Treating atherosclerosis | SCHERING CORPORATION (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0514851-A1 | N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:cholesterol acyl transferase | SCHERING CORPORATION (US) | 1992-11-25 | — | — | EP | disclosed |
| US-5124337-A | Treating atherosclerosis | SCHERING CORPORATION (US) | 1992-06-23 | — | — | US | disclosed |