Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.55 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.50 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8174537 | 0.83 | PTGDR2 (0.52) | FOLH1PTGDR2CYP19A1PLA2G2AP2RX4 | |
| SCHEMBL8173620 | 0.79 | FOLH1 (0.64) | FOLH1PTGDR2CYP19A1PLA2G2AMAPT | |
| SCHEMBL9584666 | 0.78 | PLA2G2A (0.55) | FOLH1PTGDR2CYP19A1PLA2G2AMAPT | |
| SCHEMBL4780401 | 0.77 | PLA2G2A (0.54) | FOLH1PTGDR2CYP19A1PLA2G2AMAPT | |
| SCHEMBL9584407 | 0.77 | FOLH1 (0.52) | FOLH1PTGDR2CYP19A1PLA2G2AMAPT | |
| SCHEMBL13802422 | 0.75 | PTGDR2 (0.76) | PTGDR2PLA2G2AMAPTP2RX4PLA2G1B | |
| SCHEMBL9584047 | 0.75 | GFER (0.52) | FOLH1PTGDR2CYP19A1PLA2G2AMAPT | |
| SCHEMBL15564286 | 0.74 | CYP19A1 (0.59) | FOLH1CYP19A1PLA2G2AMAPTP2RX4 | |
| SCHEMBL4209387 | 0.74 | PTGDR2 (0.74) | PTGDR2PLA2G2AMAPTPLA2G1BGFER | |
| SCHEMBL2002551 | 0.74 | PLA2G2A (0.68) | PLA2G2AABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931632-A2 | USEFUL INDOLE COMPOUNDS | Microbia Inc. (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007022501-A2 | USEFUL INDOLE COMPOUNDS | MICROBIA, INC. (US) | 2007-02-22 | — | — | WO | disclosed |