⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5663916 | 0.89 | SHBG (0.41) | — | |
| SCHEMBL23188102 | 0.87 | TRPA1 (0.31) | — | |
| SCHEMBL18432072 | 0.86 | SHBG (0.46) | — | |
| SCHEMBL24599441 | 0.86 | — | — | |
| SCHEMBL2756929 | 0.85 | — | — | |
| SCHEMBL25044891 | 0.85 | — | — | |
| SCHEMBL23467251 | 0.81 | — | — | |
| SCHEMBL24449724 | 0.81 | — | — | |
| SCHEMBL21256232 | 0.79 | IDO1 (0.33) | — | |
| SCHEMBL22768474 | 0.78 | SLC6A2 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293701-A1 | 1-Acylamino-2-Hydroxy-3-Amino- -Arylalkanes as Renin Inhibitors | VITAE PHARMACEUTICALS, INC. | 2008-11-27 | — | — | US | claimed |
| EP-1844002-A1 | 1-ACYLAMINO-2-HYDROXY-3-AMINO-W-ARYLALKANES AS RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2007-10-17 | — | — | EP | claimed |
| WO-2006083924-A1 | 1-ACYLAMINO-2-HYDROXY-3-AMINO-W-ARYLALKANES AS RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2006-08-10 | — | — | WO | claimed |
| US-20230227446-A9 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | NANJING ZHENGXIANG PHARMACEUTICALS CO., LTD. (CN) | 2023-07-20 | — | — | US | disclosed |
| US-20220213096-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | NANJING ZHENGXIANG PHARMACEUTICALS CO LTD (CN) | 2022-07-07 | — | — | US | disclosed |
| US-9611278-B2 | Soluble guanylate cyclase activators | MERCK SHARP & DOHME CORP. (US) | 2017-04-04 | — | — | US | disclosed |
| US-20080293701-A1 | 1-Acylamino-2-Hydroxy-3-Amino- -Arylalkanes as Renin Inhibitors | VITAE PHARMACEUTICALS, INC. | 2008-11-27 | — | — | US | disclosed |
| EP-1844002-A1 | 1-ACYLAMINO-2-HYDROXY-3-AMINO-W-ARYLALKANES AS RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006083924-A1 | 1-ACYLAMINO-2-HYDROXY-3-AMINO-W-ARYLALKANES AS RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2006-08-10 | — | — | WO | disclosed |
| EP-0925368-B1 | METHOD FOR PRODUCING ALCOHOLS FREE OF ENANTIOMERS | BASF AG (DE) | 2002-01-23 | — | — | EP | disclosed |
| US-6255087-B1 | FOR EXAMPLE, ENANTIOSELECTIVE REDUCTION OF 7-(1-OXOETHYL)-1,2,4-TRIAZOLO(1,5-A)PYRIMIDINE TO 7-(1-HYDROXYETHYL)-1,2,4-TRIAZOLO(1,5-A)PYRIMIDINE WITH MICROOGRANISMS IN THE PRESENCE OF GLUCOSE AS CARBON SOURCE | BASF AKTIENGESELLSCHAFT (DE) | 2001-07-03 | — | — | US | disclosed |
| EP-0925368-A1 | METHOD FOR PRODUCING ALCOHOLS FREE OF ENANTIOMERS | BASF AKTIENGESELLSCHAFT (DE) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998037221-A1 | METHOD FOR PRODUCING ALCOHOLS FREE OF ENANTIOMERS | BASF AKTIENGESELLSCHAFT (DE) | 1998-08-27 | — | — | WO | disclosed |
| WO-1998001427-A1 | PROCESS FOR PREPARING PYRAZOLONE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 1998-01-15 | — | — | WO | disclosed |