Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.42 |
| ▸ | LTK | P29376 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3340579 | 0.76 | MAPT (0.51) | ADORA1HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL4801840 | 0.73 | CHEK1 (0.43) | ADORA1CHEK1DAPK3LTKMAPK8 | |
| SCHEMBL4799024 | 0.71 | KMT2A (0.53) | ADORA1HPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL7863728 | 0.70 | ALDH1A1 (0.60) | HPGDNPC1RAB9AALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11829820 | 0.69 | ALDH1A1 (0.58) | HPGDNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4882626 | 0.67 | HPGD (0.38) | HPGDNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4959981 | 0.64 | CHEK1 (0.60) | ADORA1CHEK1DAPK3LTKMAPK8 | |
| SCHEMBL4799172 | 0.63 | MAPT (0.49) | NPC1RAB9AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL13943068 | 0.63 | ADORA1 (0.98) | ADORA1 | |
| SCHEMBL31151793 | 0.61 | HPGD (0.65) | HPGDNPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008052804-A1 | THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2008-05-08 | — | — | WO | disclosed |