Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3340839 | 0.75 | ADORA1 (0.47) | CHEK1DAPK3LTKMAPK8CSNK1A1 | |
| SCHEMBL4882593 | 0.73 | ADORA1 (0.44) | CHEK1DAPK3LTKMAPK8CSNK1A1 | |
| SCHEMBL4797913 | 0.72 | HSD17B10 (0.44) | CDK5FLT3KDM4EMAPTDAO | |
| SCHEMBL4801854 | 0.69 | FLT3 (0.35) | FLT3KDM4EMAPTDAOHPGD | |
| SCHEMBL4797971 | 0.67 | KDM4E (0.44) | CDK5FLT3KDM4EMAPTDAO | |
| SCHEMBL4795138 | 0.66 | RAB9A (0.46) | FLT3KDM4EMAPTDAOHPGD | |
| SCHEMBL4959981 | 0.65 | CHEK1 (0.60) | CHEK1DAPK3LTKMAPK8CSNK1A1 | |
| SCHEMBL4797498 | 0.64 | KDM4E (0.42) | FLT3KDM4EMAPTDAOHPGD | |
| SCHEMBL378260 | 0.63 | FLT3 (0.65) | FLT3KDM4EMAPTDAOHPGD | |
| SCHEMBL31321386 | 0.63 | CHEK1 (1.00) | CHEK1DAPK3LTKMAPK8CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008052804-A1 | THIAZOLHYDRAZIDES FOR TREATMENT OF NEURODEGENERATIVE DISEASES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2008-05-08 | — | — | WO | disclosed |