Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.64 |
| ▸ | TDO2 | P48775 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | RBP4 | P02753 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4883090 | 1.00 | IDO1 (0.64) | IDO1TDO2SMN1; SMN2LMNAHSD11B1 | |
| SCHEMBL4874554 | 0.80 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNACYP2C19NPSR1ALDH1A1 | |
| SCHEMBL4882042 | 0.74 | TAS1R3 (0.67) | SMN1; SMN2LMNANPSR1ALDH1A1HTT | |
| SCHEMBL349409 | 0.73 | HSD11B1 (0.87) | IDO1TDO2HSD11B1ALDH1A1CYP2D6 | |
| SCHEMBL4885388 | 0.73 | NPY5R (0.58) | SMN1; SMN2LMNAHSD11B1SIGMAR1CYP2C19 | |
| SCHEMBL4681025 | 0.73 | HSD11B1 (0.50) | IDO1TDO2HSD11B1SIGMAR1CYP2C19 | |
| SCHEMBL4681026 | 0.73 | HSD11B1 (0.50) | IDO1TDO2HSD11B1SIGMAR1CYP2C19 | |
| SCHEMBL8259094 | 0.73 | HSD11B1 (0.50) | IDO1TDO2HSD11B1SIGMAR1CYP2C19 | |
| SCHEMBL4876958 | 0.72 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNACYP2C19NPSR1ALDH1A1 | |
| SCHEMBL4876953 | 0.72 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNACYP2C19NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234252-A1 | Compounds Useful in Therapy | PFIZER INC | 2008-09-25 | — | — | US | disclosed |
| US-20080234252-A1 | Compounds Useful in Therapy | PFIZER INC | 2008-09-25 | — | — | US | disclosed |
| US-20080234252-A1 | Compounds Useful in Therapy | PFIZER INC | 2008-09-25 | — | — | US | disclosed |
| WO-2006123242-A1 | 1, 2, 4 -TRIAZOLE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | PFIZER LIMITED (GB) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234252-A1 | Compounds Useful in Therapy | AVPR1A, AVPR1B, AVPR2 | IDO1 3752/4885TDO2 3569/4885SMN1; SMN2 2757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.