SCHEMBL4883669

SCHEMBL4883669

O=S(=O)(NCc1ccncc1)c1ccc(Br)c(F)c1

nearest known ligand 0.67

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 6/20 0.60
NPC1 O15118 3/20 0.60
SMN1; SMN2 Q16637 10/20 0.57
HTT P42858 8/20 0.57
LMNA P02545 8/20 0.57
NR2F2 P24468 4/20 0.53
NOD2 Q9HC29 1/20 0.53
ALDH1A1 P00352 1/20 0.51
GALR3 O60755 2/20 0.51
NAMPT P43490 2/20 0.49
MEN1 O00255 1/20 0.49
PKM P14618 1/20 0.49
TSHR P16473 1/20 0.49
KMT2A Q03164 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL120400 0.86 PKM (0.61) SMN1; SMN2LMNAALDH1A1PKMKMT2A
SCHEMBL14034664 0.84 RAB9A (0.58) RAB9ANPC1SMN1; SMN2HTTLMNA
SCHEMBL17372926 0.81 RAB9A (0.77) RAB9ANPC1SMN1; SMN2HTTLMNA
SCHEMBL3923271 0.79 SMN1; SMN2 (0.71) RAB9ANPC1SMN1; SMN2HTTLMNA
SCHEMBL17372930 0.77 SMN1; SMN2 (0.68) RAB9ANPC1SMN1; SMN2HTTLMNA
SCHEMBL3006563 0.76 ALDH1A1 (0.63) SMN1; SMN2ALDH1A1KMT2A
SCHEMBL14419632 0.75 RAB9A (0.77) RAB9ANPC1SMN1; SMN2HTTLMNA
SCHEMBL3025163 0.74 CNR2 (0.57) NPC1SMN1; SMN2ALDH1A1MEN1PKM
SCHEMBL31113705 0.74 PKM (0.65) SMN1; SMN2LMNAALDH1A1PKMKMT2A
SCHEMBL27083360 0.74 SMN1; SMN2 (0.73) RAB9ANPC1SMN1; SMN2HTTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1860941-B1 BIPHENYL-N-(4-PYRIDYL) METHYLSUFONAMIDES BASF SE (DE) 2008-11-12 EP disclosed
EP-1860941-B1 BIPHENYL-N-(4-PYRIDYL) METHYLSUFONAMIDES BASF SE (DE) 2008-11-12 EP disclosed
US-20080161187-A1 Controlling phytopathogenic harmful fungi and harmful arthropodes; combating arthropodal pestsprotecting crops, seeds and non-living materials from infestation by arthropodal pests; insecticides, pesticides, fungicides; miticides; agriculture; veterinary medicine BASF AKTIENGESELLSCHAFT (DE) 2008-07-03 US disclosed
US-20080161187-A1 Controlling phytopathogenic harmful fungi and harmful arthropodes; combating arthropodal pestsprotecting crops, seeds and non-living materials from infestation by arthropodal pests; insecticides, pesticides, fungicides; miticides; agriculture; veterinary medicine BASF AKTIENGESELLSCHAFT (DE) 2008-07-03 US disclosed
US-20080161187-A1 Controlling phytopathogenic harmful fungi and harmful arthropodes; combating arthropodal pestsprotecting crops, seeds and non-living materials from infestation by arthropodal pests; insecticides, pesticides, fungicides; miticides; agriculture; veterinary medicine BASF AKTIENGESELLSCHAFT (DE) 2008-07-03 US disclosed
CN-101141878-A Biphenyl-n-(4-pyridyl)methylsulfonamides BASF AG (DE) 2008-03-12 CN disclosed
EP-1860941-A1 BIPHENYL-N-(4-PYRIDYL) METHYLSUFONAMIDES BASF AKTIENGESELLSCHAFT (DE) 2007-12-05 EP disclosed
WO-2006097489-A1 BIPHENYL-N-(4-PYRIDYL) METHYLSUFONAMIDES BASF AKTIENGESELLSCHAFT (DE) 2006-09-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080161187-A1 Controlling phytopathogenic harmful fungi and harmful arthropodes; combating arthropodal pestsprotecting crops, seeds and non-living materials from infestation by arthropodal pests; insecticides, pesticides, fungicides; miticides; agriculture; veterinary medicine PTPN21, PTPN1, PTPN14 RAB9A 2586/4885NPC1 1358/4885SMN1; SMN2 2697/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.