SCHEMBL4884726

SCHEMBL4884726

CCCC(CCN(O)C=O)C(=O)NC(C(=O)N1CCC(NC(=O)c2ccc(C(F)(F)F)cc2)CC1)C(C)(C)C

nearest known ligand 0.45

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PDF Q9HBH1 1/20 0.45
TSHR P16473 1/20 0.43
SLC6A5 Q9Y345 8/20 0.42
EPHX2 P34913 6/20 0.41
TEAD1 P28347 1/20 0.40
PHGDH O43175 1/20 0.39
DRD2 P14416 1/20 0.39
DRD4 P21917 1/20 0.39
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4884713 1.00 PDF (0.45) PDFTSHRSLC6A5EPHX2TEAD1
SCHEMBL14066497 0.86 TSHR (0.44) TSHRSLC6A5EPHX2TEAD1PHGDH
SCHEMBL4883080 0.85 TSHR (0.41) TSHRSLC6A5EPHX2TEAD1PHGDH
SCHEMBL4603077 0.85 TSHR (0.41) TSHRSLC6A5EPHX2TEAD1PHGDH
SCHEMBL4604487 0.82 KMT2A (0.41) PDFTSHRMEN1KMT2A
SCHEMBL4601223 0.81 PDF (0.42) PDFTSHRMEN1KMT2A
SCHEMBL4884598 0.81 PDF (0.42) PDFTSHRMEN1KMT2A
SCHEMBL4884729 0.81 TSHR (0.45) TSHRSLC6A5EPHX2TEAD1PHGDH
SCHEMBL4602747 0.81 PDF (0.41) PDFTSHR
SCHEMBL4602320 0.80 NPSR1 (0.46) PDFMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080234333-A1 Novel Hydroxamic Acid Derivative as Peptide Deformylase Inhibitor and Manufacturing Method Thereof KANG JAE-HOON 2008-09-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080234333-A1 Novel Hydroxamic Acid Derivative as Peptide Deformylase Inhibitor and Manufacturing Method Thereof PDF, PEPD, DHPS PDF 1/4885TSHR 3586/4885SLC6A5 2392/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.