SCHEMBL4602747

SCHEMBL4602747

CCCC[C@H](CN(O)C=O)C(=O)N[C@H](C(=O)N1CCC(NC(=O)c2ccc(Br)cc2)CC1)C(C)(C)C

nearest known ligand 0.44

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PDF Q9HBH1 2/20 0.41
TSHR P16473 1/20 0.41
MMP2 P08253 1/20 0.40
MMP3 P08254 1/20 0.40
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
UTS2R Q9UKP6 2/20 0.38
ITGB3 P05106 2/20 0.38
ITGA2B P08514 2/20 0.38
BMP1 P13497 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4601223 0.93 PDF (0.42) PDFTSHRLMNABMP1
SCHEMBL4884598 0.93 PDF (0.42) PDFTSHRLMNABMP1
SCHEMBL4604487 0.92 KMT2A (0.41) PDFTSHRMMP2MMP3
SCHEMBL4602320 0.92 NPSR1 (0.46) PDFMMP2MMP3BMP1
SCHEMBL4602355 0.91 KMT2A (0.43) PDFTSHRMMP2MMP3ALDH1A1
SCHEMBL4603826 0.89 TSHR (0.39) TSHRALDH1A1LMNASMN1; SMN2
SCHEMBL4902899 0.89 TSHR (0.39) TSHRALDH1A1LMNASMN1; SMN2
SCHEMBL14066489 0.85 MMP3 (0.51) PDFMMP2MMP3BMP1
SCHEMBL4616327 0.85 MMP3 (0.51) PDFMMP2MMP3BMP1
SCHEMBL14066495 0.84 MMP2 (0.45) PDFMMP2MMP3BMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080234333-A1 Novel Hydroxamic Acid Derivative as Peptide Deformylase Inhibitor and Manufacturing Method Thereof KANG JAE-HOON 2008-09-25 US disclosed
US-20080234333-A1 Novel Hydroxamic Acid Derivative as Peptide Deformylase Inhibitor and Manufacturing Method Thereof KANG JAE-HOON 2008-09-25 US disclosed
US-20080234333-A1 Novel Hydroxamic Acid Derivative as Peptide Deformylase Inhibitor and Manufacturing Method Thereof KANG JAE-HOON 2008-09-25 US disclosed
EP-1915342-A1 A NOVEL HYDROXAMIC ACID DERIVATIVE AS PEPTIDE DEFORMYLASE INHIBITOR AND MANUFACTURING METHOD THEREOF Ildong Pharmaceutical Co., Ltd. (KR) 2008-04-30 EP disclosed
WO-2006115353-A9 A NOVEL HYDROXAMIC ACID DERIVATIVE AS PEPTIDE DEFORMYLASE INHIBITOR AND MANUFACTURING METHOD THEREOF ILDONG PHARMACEUTICAL CO LTD (KR) 2007-03-22 WO disclosed
WO-2006115353-A1 A NOVEL HYDROXAMIC ACID DERIVATIVE AS PEPTIDE DEFORMYLASE INHIBITOR AND MANUFACTURING METHOD THEREOF ILDONG PHARMACEUTICAL CO., LTD. (KR) 2006-11-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080234333-A1 Novel Hydroxamic Acid Derivative as Peptide Deformylase Inhibitor and Manufacturing Method Thereof PDF, PEPD, DHPS PDF 1/4885TSHR 3586/4885MMP2 315/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.