Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4881106 | 0.82 | CACNA1B (0.34) | NR1H2MAPK1ELANENPC1RAB9A | |
| SCHEMBL26205734 | 0.78 | MAPK1 (0.43) | CYP1A2CYP3A4CYP2C9CYP2C19MAPK1 | |
| SCHEMBL907526 | 0.75 | LMNA (0.37) | ELANEMAPTALDH1A1KDM4EITGA4 | |
| SCHEMBL14423544 | 0.74 | ELANE (0.39) | ELANEMAPTLMNA | |
| SCHEMBL13279340 | 0.73 | PTGS2 (0.44) | CYP1A2CYP3A4CYP2C9CYP2C19MAPK1 | |
| SCHEMBL14164203 | 0.73 | NR1H2 (0.47) | NR1H2NPC1RAB9AMAPTPKM | |
| SCHEMBL24966942 | 0.72 | MAPK1 (0.62) | CYP1A2CYP3A4CYP2C9CYP2C19MAPK1 | |
| SCHEMBL1966568 | 0.71 | NR1H2 (0.39) | NR1H2MAPK1NPC1RAB9AMAPT | |
| SCHEMBL2124198 | 0.71 | CYP1A2 (0.42) | CYP1A2CYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL908480 | 0.70 | NR1H2 (0.34) | NR1H2MAPK1NPC1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080227774-A1 | 5,5-DISUBSTITUTED-INDOLIZINONE COMPOUNDS | ANADYS PHARMACEUTICALS, INC. | 2008-09-18 | — | — | US | disclosed |
| US-20080227774-A1 | 5,5-DISUBSTITUTED-INDOLIZINONE COMPOUNDS | ANADYS PHARMACEUTICALS, INC. | 2008-09-18 | — | — | US | disclosed |
| US-20080227774-A1 | 5,5-DISUBSTITUTED-INDOLIZINONE COMPOUNDS | ANADYS PHARMACEUTICALS, INC. | 2008-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080227774-A1 | 5,5-DISUBSTITUTED-INDOLIZINONE COMPOUNDS | CYP3A5, IPO5, IDO1 | CYP1A2 49/4885CYP3A4 20/4885CYP2C9 61/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.