Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4885733 | 0.86 | CYP3A4 (0.47) | ALDH1A1GAAMAPTHTTSMN1; SMN2 | |
| SCHEMBL3554974 | 0.84 | ALDH1A1 (0.48) | ALDH1A1GAAMAPTHTTSMN1; SMN2 | |
| SCHEMBL3564749 | 0.81 | ALDH1A1 (0.49) | ALDH1A1GAAMAPTHTTSMN1; SMN2 | |
| SCHEMBL2572266 | 0.80 | ABL1 (0.55) | ALDH1A1GAAMAPTKMT2AMEN1 | |
| SCHEMBL3569040 | 0.79 | ALDH1A1 (0.55) | ALDH1A1GAAMAPTHTTSMN1; SMN2 | |
| SCHEMBL14146775 | 0.79 | ALDH1A1 (0.59) | ALDH1A1GAAMAPTHTTSMN1; SMN2 | |
| SCHEMBL783033 | 0.76 | MAPK10 (0.49) | ALDH1A1GAAABL1EGFRBCR | |
| SCHEMBL4264785 | 0.76 | KARS1 (0.54) | ALDH1A1GAAKMT2AMEN1ABL1 | |
| SCHEMBL3562948 | 0.76 | CYP1A2 (0.47) | ALDH1A1GAAKMT2AMEN1HPGD | |
| SCHEMBL13316448 | 0.74 | ALDH1A1 (0.56) | ALDH1A1GAAMAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080146570-A1 | Chemical Compounds | ASTRAZENECA AB (SE) | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146570-A1 | Chemical Compounds | BRAF, RAF1, NRAS | ALDH1A1 260/4885GAA 2787/4885MAPT 3149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.