SCHEMBL4886038

SCHEMBL4886038

CC(C)(C)[Si](C)(C)OCCNc1ccc(NC(=O)c2nccnc2C(=O)Nc2ccc(C#N)cn2)cc1

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.40
MEN1 O00255 1/20 0.39
TMPRSS4 Q9NRS4 1/20 0.38
MAPT P10636 1/20 0.38
DGAT1 O75907 1/20 0.38
PANK3 Q9H999 1/20 0.36
BACE1 P56817 1/20 0.36
MLYCD O95822 1/20 0.35
IRAK4 Q9NWZ3 1/20 0.35
NPC1 O15118 1/20 0.35
ALDH1A1 P00352 1/20 0.35
TP53 P04637 1/20 0.35
PKM P14618 1/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
DEGS1 O15121 1/20 0.35
PORCN Q9H237 1/20 0.35
DPP4 P27487 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4882033 0.92 MLYCD (0.42) KMT2AMAPTMLYCDNPC1ALDH1A1
SCHEMBL4881605 0.87 KMT2A (0.43) KMT2AMAPTDGAT1NPC1ALDH1A1
SCHEMBL4881302 0.86 KMT2A (0.38) KMT2AMEN1TMPRSS4MAPTPANK3
SCHEMBL4710501 0.86 RAB9A (0.42) KMT2AMEN1MAPTDGAT1NPC1
SCHEMBL4881556 0.84 MAPT (0.42) MAPTDGAT1NPC1ALDH1A1TP53
SCHEMBL4875148 0.81 RAB9A (0.41) KMT2AMEN1MAPTNPC1ALDH1A1
SCHEMBL4881687 0.77 SIRT2 (0.37) KMT2AMAPTMLYCDNPC1ALDH1A1
SCHEMBL15739737 0.76 CETP (0.44) KMT2AMEN1ALDH1A1
SCHEMBL4878081 0.76 KMT2A (0.38) KMT2AMEN1MAPTNPC1ALDH1A1
SCHEMBL4881051 0.76 RAB9A (0.38) KMT2AMEN1MAPTNPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080214533-A1 Cyclic Iminocarbamates And Their Use BAYER HEALTHCARE AG (DE) 2008-09-04 US disclosed
US-20080214533-A1 Cyclic Iminocarbamates And Their Use BAYER HEALTHCARE AG (DE) 2008-09-04 US disclosed
EP-1819701-A1 CYCLIC IMINOCARBAMATES AND USE THEREOF Bayer HealthCare AG (DE) 2007-08-22 EP disclosed
WO-2006058630-A1 CYCLIC IMINOCARBAMATES AND USE THEREOF BAYER HEALTHCARE AG (DE) 2006-06-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080214533-A1 Cyclic Iminocarbamates And Their Use F2, UQCRB, F12 KMT2A 3720/4885MEN1 251/4885TMPRSS4 3549/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.