Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHAT | P28329 | 4/20 | 0.58 |
| ▸ | RAD52 | P43351 | 3/20 | 0.56 |
| ▸ | APP | P05067 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 5/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | PKM | P14618 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | NSD2 | O96028 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL4886952 | 1.00 | CHAT (0.58) | CHATRAD52APPHTTNPSR1 | |
| Iodide SCHEMBL4883348 | 0.86 | MEN1 (0.60) | CHATRAD52APPHTTNPSR1 | |
| Iodide SCHEMBL4883351 | 0.86 | MEN1 (0.60) | CHATRAD52APPHTTNPSR1 | |
| SCHEMBL15911974 | 0.79 | CHAT (0.62) | CHATRAD52APPHTTNPSR1 | |
| Iodide SCHEMBL6858541 | 0.77 | CHAT (0.67) | CHATRAD52APPHTTNPSR1 | |
| Iodide SCHEMBL6858540 | 0.77 | CHAT (0.67) | CHATRAD52APPHTTNPSR1 | |
| SCHEMBL12686413 | 0.75 | HTT (0.70) | CHATRAD52APPHTTNPSR1 | |
| SCHEMBL12866151 | 0.75 | CHAT (0.67) | CHATRAD52APPHTTNPSR1 | |
| Iodide SCHEMBL6559481 | 0.74 | CHAT (0.62) | CHATRAD52APPHTTNPSR1 | |
| SCHEMBL13766059 | 0.74 | CHAT (0.79) | CHATRAD52APPHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113944-A1 | Novel Indole Derivatives | NOVO NORDISK A/S (DK) | 2008-05-15 | — | — | US | claimed |
| US-20080113944-A1 | Novel Indole Derivatives | NOVO NORDISK A/S (DK) | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113944-A1 | Novel Indole Derivatives | GPR119, FABP4, MC4R | CHAT 1267/4885RAD52 3681/4885APP 4818/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.