Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | RAD52 | P43351 | 2/20 | 0.60 |
| ▸ | NSD2 | O96028 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | PPARG | P37231 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL4883348 | 1.00 | MEN1 (0.60) | MEN1NPC1RAB9AKMT2ARAD52 | |
| Iodide SCHEMBL4886952 | 0.86 | CHAT (0.58) | MEN1NPC1RAB9AKMT2ARAD52 | |
| Iodide SCHEMBL4886944 | 0.86 | CHAT (0.58) | MEN1NPC1RAB9AKMT2ARAD52 | |
| SCHEMBL29053033 | 0.77 | MEN1 (0.73) | MEN1NPC1RAB9AKMT2ARAD52 | |
| Iodide SCHEMBL6560159 | 0.77 | KMT2A (0.73) | MEN1NPC1RAB9AKMT2ARAD52 | |
| Iodide SCHEMBL6858988 | 0.77 | KMT2A (0.73) | MEN1NPC1RAB9AKMT2ARAD52 | |
| SCHEMBL9455035 | 0.75 | MEN1 (0.70) | MEN1NPC1RAB9AKMT2ARAD52 | |
| SCHEMBL9455038 | 0.75 | MEN1 (0.70) | MEN1NPC1RAB9AKMT2ARAD52 | |
| Iodide SCHEMBL6851868 | 0.75 | KDM4E (0.60) | MEN1NPC1RAB9AKMT2ARAD52 | |
| Iodide SCHEMBL6851867 | 0.75 | KDM4E (0.60) | MEN1NPC1RAB9AKMT2ARAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080113944-A1 | Novel Indole Derivatives | NOVO NORDISK A/S (DK) | 2008-05-15 | — | — | US | claimed |
| EP-1758856-A2 | INDOLE DERIVATIVES FOR THE TREATMENT OF OBESITY | NOVO NORDISK A/S (DK) | 2007-03-07 | — | — | EP | claimed |
| WO-2005105785-A2 | INDOLE DERIVATIVES FOR TREATMENT OF OBESITY | NOVO NORDISK A/S (DK) | 2005-11-10 | — | — | WO | claimed |
| US-20080113944-A1 | Novel Indole Derivatives | NOVO NORDISK A/S (DK) | 2008-05-15 | — | — | US | disclosed |
| EP-1758856-A2 | INDOLE DERIVATIVES FOR THE TREATMENT OF OBESITY | NOVO NORDISK A/S (DK) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005105785-A2 | INDOLE DERIVATIVES FOR TREATMENT OF OBESITY | NOVO NORDISK A/S (DK) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113944-A1 | Novel Indole Derivatives | GPR119, FABP4, MC4R | MEN1 4434/4885NPC1 4064/4885RAB9A 3369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.