SCHEMBL4886947

SCHEMBL4886947

N#CCCOP(=O)(Cl)Cl

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10698483 0.85 ALDH1A1 (0.33)
SCHEMBL29285247 0.81
SCHEMBL733409 0.79 ALDH1A1 (0.43)
SCHEMBL29285237 0.77
SCHEMBL28408950 0.76 ALDH1A1 (0.37)
SCHEMBL22652 0.75
Water SCHEMBL6908198 0.75 LPAR3 (0.41)
SCHEMBL413500 0.75
SCHEMBL497349 0.75 P2RY14 (0.34)
SCHEMBL2180334 0.75 ALDH1A1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113004328-A Voriconazole phosphocholine inner salt intermediate, preparation method and method for preparing voriconazole phosphocholine inner salt 重庆西米瑞医药技术有限公司 2021-06-22 CN claimed
CN-108627647-B Detection and quantification method of post-translational modification proteomics 四川大学 2020-06-19 CN claimed
JP-59141591-A None JP disclosed
US-20260049309-A1 REGULATION OF ACTIVITY OF RNAI MOLECULES NOVO NORDISK AS (DE) 2026-02-19 US disclosed
US-20250122500-A1 RNAi OLIGONUCLEOTIDE CONJUGATES NOVO NORDISK A/S (DK) 2025-04-17 US disclosed
WO-2025054459-A1 RNAI OLIGONUCLEOTIDE CONJUGATES DICERNA PHARMACEUTICALS, INC. (US) 2025-03-13 WO disclosed
CN-115043874-B Preparation method and application of tri (2-cyanoethyl) phosphite ester 山东海科创新研究院有限公司 2024-11-08 CN disclosed
EP-4426432-A1 LIPID CONJUGATION FOR TARGETING OLIGODENDROCYTES OF THE CENTRAL NERVOUS SYSTEM Dicerna Pharmaceuticals, Inc. (US) 2024-09-11 EP disclosed
EP-4426839-A1 LIPID CONJUGATION FOR TARGETING ASTROCYTES OF THE CENTRAL NERVOUS SYSTEM Dicerna Pharmaceuticals, Inc. (US) 2024-09-11 EP disclosed
US-20240287512-A1 LIPID CONJUGATION FOR TARGETING NEURONS OF THE CENTRAL NERVOUS SYSTEM NOVO NORDISK A/S (DK) 2024-08-29 US disclosed
CN-118271360-A Fluorinated phosphate, preparation method thereof, nonaqueous electrolyte containing fluorinated phosphate and electrochemical device 深圳市研一新材料有限责任公司 2024-07-02 CN disclosed
EP-4021915-A1 LIGAND-2'-MODIFIED NUCLEIC ACIDS, SYNTHESIS THEREOF AND INTERMEDIATE COMPOUNDS THEREOF Dicerna Pharmaceuticals, Inc. (US) 2022-07-06 EP disclosed
WO-2021146488-A1 4'-O-METHYLENE PHOSPHONATE NUCLEIC ACIDS AND ANALOGUES THEREOF DICERNA PHARMACEUTICALS, INC. (US) 2021-07-22 WO disclosed
CN-113004328-A Voriconazole phosphocholine inner salt intermediate, preparation method and method for preparing voriconazole phosphocholine inner salt 重庆西米瑞医药技术有限公司 2021-06-22 CN disclosed
WO-2021041756-A1 LIGAND-2'-MODIFIED NUCLEIC ACIDS, SYNTHESIS THEREOF AND INTERMEDIATE COMPOUNDS THEREOF DICERNA PHARMACEUTICALS, INC. (US) 2021-03-04 WO disclosed
US-20080119645-A1 Immobilization; solid phase synthesis ISIS PHARMACEUTICALS, INC. (US) 2008-05-22 US disclosed
WO-2005108411-A2 SUBSTITUTED PIXYL PROTECTING GROUPS FOR OLIGONUCLEOTIDE SYNTHESIS ISIS PHARMACEUTICALS, INC. (US) 2005-11-17 WO disclosed
EP-1165575-A1 PHOSPHATE CONTAINING MACROCYCLIC IMMUNOMODULATORS ABBOTT LABORATORIES (US) 2002-01-02 EP disclosed
WO-2000058318-A1 PHOSPHATE CONTAINING MACROCYCLIC IMMUNOMODULATORS ABBOTT LABORATORIES (US) 2000-10-05 WO disclosed
JP-S59141591-A PREPARATION OF AMMONIUM (5-IODO-3-INDOLYL) 5'-THYMIDYLATE FUJIREBIO INC 1984-08-14 JP disclosed