Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10643684 | 0.83 | MAOA (0.47) | ALDH1A1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL11037499 | 0.83 | MAOA (0.47) | ALDH1A1SMN1; SMN2HPGDKDM4EMAOA | |
| SCHEMBL11140209 | 0.83 | MAOA (0.47) | ALDH1A1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL11662672 | 0.83 | MAOA (0.47) | ALDH1A1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL1983880 | 0.83 | TDP1 (0.51) | ALDH1A1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL1984980 | 0.83 | MAOA (0.47) | HPGDMAOAACHECES1BCHE | |
| SCHEMBL23839 | 0.82 | MAOA (0.57) | ALDH1A1RAB9ASMN1; SMN2MAPTLMNA | |
| SCHEMBL9182598 | 0.80 | ADORA2A (0.40) | ALDH1A1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL8155246 | 0.80 | CA1 (0.46) | ALDH1A1MAOACES1BCHETDP1 | |
| SCHEMBL3380386 | 0.80 | KDM4E (0.49) | ALDH1A1NPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180256617-A1 | METHODS FOR EXTENDING LIFESPAN AND METHODS OF SCREENING KNOWN PHARMACOLOGICAL AGENTS FOR NEW USES | LONGEVICA THERAPEUTICS INC. | 2018-09-13 | — | — | US | claimed |
| WO-2016168670-A2 | METHODS FOR EXTENDING LIFESPAN AND METHODS OF SCREENING KNOWN PHARMACOLOGICAL AGENTS FOR NEW USES | LONGEVICA THERAPEUTICS INC. (US) | 2016-10-20 | — | — | WO | claimed |
| US-4288362-A | Monoazo pigments containing a quinazo linonylacetoacetanilide coupling component | BAYER AKTIENGESELLSCHAFT (DE) | 1981-09-08 | — | — | US | claimed |
| US-20240024353-A1 | METHODS AND COMPOSITIONS FOR EXTENDING LIFESPAN | LONGEVICA THERAPEUTICS INC. (US) | 2024-01-25 | — | — | US | disclosed |
| US-20210283173-A1 | METHODS AND COMPOSITIONS FOR EXTENDING LIFESPAN | LONGEVICA THERAPEUTICS INC. (US) | 2021-09-16 | — | — | US | disclosed |
| US-10882861-B2 | Purine nucleotide derivatives | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2021-01-05 | — | — | US | disclosed |
| US-20200254006-A1 | METHODS AND COMPOSITIONS FOR EXTENDING LIFESPAN | LONGEVICA THERAPEUTICS INC. (US) | 2020-08-13 | — | — | US | disclosed |
| US-10653715-B2 | Methods and compositions for extending lifespan | Longevica Theraputics Inc. (US) | 2020-05-19 | — | — | US | disclosed |
| US-20190300532-A1 | PURINE NUCLEOTIDE DERIVATIVES | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2019-10-03 | — | — | US | disclosed |
| US-20180256617-A1 | METHODS FOR EXTENDING LIFESPAN AND METHODS OF SCREENING KNOWN PHARMACOLOGICAL AGENTS FOR NEW USES | LONGEVICA THERAPEUTICS INC. | 2018-09-13 | — | — | US | disclosed |
| WO-2018075641-A1 | METHODS AND COMPOSITIONS FOR EXTENDING LIFESPAN | LONGEVICA THERAPEUTICS INC. (US) | 2018-04-26 | — | — | WO | disclosed |
| US-4831140-A | Process for the preparation of arylimides of perylene-3,4,9,10-tetracarboxylic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-05-16 | — | — | US | disclosed |
| EP-0198369-A2 | Process for the preparation of perylene-3,4,9,10-tetracarboxylic-acid aryl imides | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-10-22 | — | — | EP | disclosed |
| EP-0008627-B1 | QUINAZOLINE DERIVATIVES, AZO DYES DERIVED FROM THE QUINAZOLINES AND THEIR USE AS PIGMENTS | BAYER AG (DE) | 1984-10-03 | — | — | EP | disclosed |
| US-4288362-A | Monoazo pigments containing a quinazo linonylacetoacetanilide coupling component | BAYER AKTIENGESELLSCHAFT (DE) | 1981-09-08 | — | — | US | disclosed |
| EP-0008627-A2 | Quinazoline derivatives, azo dyes derived from the quinazolines and their use as pigments | BAYER AG (DE) | 1980-03-19 | — | — | EP | disclosed |
| US-4083725-A | CINNAMIC ACID PHOTOSENSITIVE RESIN AND A HALOGEN SUBSTITUTED BENZANTHRONE SENSITIZER | MITSUBISHI CHEMICAL INDUSTRIES LTD. (JA) | 1978-04-11 | — | — | US | disclosed |
| US-4076713-A | Indanthrene dyes | PRODUITS CHIMIQUES UGINE KUHLMANN (FR) | 1978-02-28 | — | — | US | disclosed |
| US-3971740-A | DYES FOR POLYESTER FIBERS | CIBA-GEIGY AG (CH) | 1976-07-27 | — | — | US | disclosed |
| US-3945989-A | Fluoro triazine containing water insoluble azo dyestuff | CIBA-GEIGY AG (CH) | 1976-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10882861-B2 | Purine nucleotide derivatives | PNP, NT5C2, NUDT1 | ALDH1A1 1223/4885NPC1 642/4885RAB9A 2856/4885 |
| US-20190300532-A1 | PURINE NUCLEOTIDE DERIVATIVES | PNP, NT5C2, NUDT1 | ALDH1A1 1223/4885NPC1 642/4885RAB9A 2856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.