⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4888767 | 0.87 | GPR119 (0.30) | — | |
| SCHEMBL4879978 | 0.85 | GPR119 (0.38) | — | |
| SCHEMBL4885449 | 0.81 | MCHR1 (0.48) | — | |
| SCHEMBL4881680 | 0.80 | PRKDC (0.32) | — | |
| SCHEMBL4886218 | 0.78 | MCHR1 (0.44) | — | |
| SCHEMBL1781268 | 0.72 | HRH4 (0.35) | — | |
| SCHEMBL4888760 | 0.65 | MCHR1 (0.47) | — | |
| SCHEMBL4879972 | 0.63 | GPR119 (0.50) | — | |
| SCHEMBL7078416 | 0.62 | ALDH1A1 (0.48) | — | |
| SCHEMBL7814936 | 0.62 | ALDH1A1 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008041090-A1 | MALANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONIST PYRIDINONES | PFIZER LIMITED (GB) | 2008-04-10 | — | — | WO | disclosed |
| US-20080085884-A1 | Melanin Concentrating Hormone Receptor-1 Antagonist Pyridinones | PFIZER INC | 2008-04-10 | — | — | US | disclosed |