Sugi Predict

Sugi Predict / Compounds / SCHEMBL4887683

SCHEMBL4887683

SCHEMBL4887683

c1ccc(Cn2c(-c3ccccc3)cc3ccccc32)cc1

nearest known ligand 0.61

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 1/20 0.61
▸ PTGS2 P35354 1/20 0.58
▸ ALDH1A1 P00352 2/20 0.58
▸ ESR1 P03372 6/20 0.57
▸ CCR2 P41597 3/20 0.57
▸ KMT2A Q03164 2/20 0.54
▸ PDE6D O43924 1/20 0.50
▸ ALDH2 P05091 1/20 0.50
▸ ALDH3A1 P30838 1/20 0.50
▸ MTNR1A P48039 1/20 0.49
▸ MTNR1B P49286 1/20 0.49
▸ CYP19A1 P11511 1/20 0.48
▸ LMNA P02545 1/20 0.47
▸ SMN1; SMN2 Q16637 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6086162 0.90 PTGS2 (0.71) L3MBTL1PTGS2ALDH1A1ESR1CCR2
SCHEMBL28384928 0.89 CCR2 (0.64) L3MBTL1PTGS2ALDH1A1ESR1CCR2
SCHEMBL2823906 0.89 L3MBTL1 (0.57) L3MBTL1PTGS2ALDH1A1ESR1CCR2
SCHEMBL16632290 0.87 PTGS2 (0.53) L3MBTL1PTGS2ALDH1A1ESR1CCR2
SCHEMBL5075270 0.86 PTGS2 (0.53) L3MBTL1PTGS2ALDH1A1ESR1CCR2
SCHEMBL28385496 0.86 CCR2 (0.64) L3MBTL1PTGS2ALDH1A1ESR1CCR2
SCHEMBL2823882 0.86 L3MBTL1 (0.55) L3MBTL1PTGS2ALDH1A1ESR1CCR2
SCHEMBL28387470 0.86 ESR1 (0.53) L3MBTL1PTGS2ALDH1A1ESR1CCR2
SCHEMBL11993908 0.85 PTGS2 (0.55) L3MBTL1PTGS2ALDH1A1ESR1CCR2
SCHEMBL1368052 0.85 L3MBTL1 (0.61) L3MBTL1PTGS2ALDH1A1CCR2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109400518-B Polysubstituted 6-arylbenzo [ a ] carbazole derivative and synthetic method thereof 湘潭大学 2021-09-24 — — CN claimed
CN-108997329-B Polysubstituted 3- (3-benzo [ b ] selenophenyl) -1H-2-aryl indole and derivative and synthesis method thereof 湘潭大学 2021-06-04 — — CN claimed
CN-119019310-A Indole vinyl sulfonyl fluoride compound and preparation method thereof 武汉理工大学 2024-11-26 — — CN disclosed
CN-109400518-B Polysubstituted 6-arylbenzo [ a ] carbazole derivative and synthetic method thereof 湘潭大学 2021-09-24 — — CN disclosed
WO-2021143816-A1 FUSED IMIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF 江苏恒瑞医药股份有限公司 2021-07-22 — — WO disclosed
CN-108997329-B Polysubstituted 3- (3-benzo [ b ] selenophenyl) -1H-2-aryl indole and derivative and synthesis method thereof 湘潭大学 2021-06-04 — — CN disclosed
CN-111087391-A 4-indole quinazoline compound and preparation method and application thereof 郑州大学 2020-05-01 — — CN disclosed
WO-2017138756-A1 COMPOUND, COLOR MATERIAL COMPOSITION COMPRISING SAME AND RESIN COMPOSITION COMPRISING SAME 주식회사 엘지화학 2017-08-17 — — WO disclosed
US-20110049444-A1 COLORED RESIN COMPOSITIONS FOR COLOR FILTER, COLOR FILTER, ORGANIC EL DISPLAY, AND LIQUID-CRYSTAL DISPLAY DEVICE MITSUBISHI CHEMICAL CORPORATION (JP) 2011-03-03 — — US disclosed
US-20110049444-A1 COLORED RESIN COMPOSITIONS FOR COLOR FILTER, COLOR FILTER, ORGANIC EL DISPLAY, AND LIQUID-CRYSTAL DISPLAY DEVICE MITSUBISHI CHEMICAL CORPORATION (JP) 2011-03-03 — — US disclosed
US-20080039625-A1 Screening Methods LAUTENS MARK 2008-02-14 — — US disclosed
EP-0997465-B1 Azaindole derivatives and their use as antithrombotic agents LILLY CO ELI (US) 2004-02-04 — — EP disclosed
EP-0802184-B1 N-Benzyl-2-phenylindoles as estrogenic agents WYETH CORP (US) 2002-06-19 — — EP disclosed
EP-0802184-A1 N-Benzyl-2-phenylindoles as estrogenic agents AMERICAN HOME PRODUCTS CORPORATION (US) 1997-10-22 — — EP disclosed
US-5245046-A α-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents THE UPJOHN COMPANY (US) 1993-09-14 — — US disclosed
EP-0375133-A1 Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents THE UPJOHN COMPANY (US) 1990-06-27 — — EP disclosed
WO-1990005721-A1 ALPHA-AMINO-INDOLE-3-ACETIC ACIDS USEFUL AS ANTI-DIABETIC, ANTI-OBESITY AND ANTI-ATHEROSCLEROTIC AGENTS THE UPJOHN COMPANY (US) 1990-05-31 — — WO disclosed
US-4104268-A POLYACRYLONITRILE, POLYESTERS, POLYAMIDES BAYER AKTIENGESELLSCHAFT (DE) 1978-08-01 — — US disclosed
US-4026931-A AZO DYES, FIBER-REACTIVE; INDOLE OR 5-AMINO-PYRAZOLE COUPLING COMPONENT BAYER AKTIENGESELLSCHAFT (DT) 1977-05-31 — — US disclosed
US-4006127-A Cationic diazacyanine dyestuffs BAYER AKTIENGESELLSCHAFT (DT) 1977-02-01 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080039625-A1 Screening Methods CBR3, ZKSCAN2, CRBN L3MBTL1 388/4885PTGS2 4625/4885ALDH1A1 2175/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.