Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30553986 | 1.00 | DPP4 (0.38) | DPP4ALDH1A1KDM4EHSD17B10MEN1 | |
| SCHEMBL30765124 | 0.87 | CES2 (0.39) | ALDH1A1KDM4EMEN1LMNAHTT | |
| SCHEMBL5805576 | 0.87 | CES2 (0.39) | ALDH1A1KDM4EMEN1LMNAHTT | |
| SCHEMBL15400757 | 0.86 | DPP4 (0.34) | DPP4ALDH1A1KDM4EHSD17B10MEN1 | |
| SCHEMBL29443058 | 0.83 | PKM (0.41) | DPP4ALDH1A1KDM4EHSD17B10MEN1 | |
| SCHEMBL22905069 | 0.83 | PKM (0.41) | DPP4ALDH1A1KDM4EHSD17B10MEN1 | |
| SCHEMBL3101770 | 0.83 | NOTUM (0.37) | DPP4ALDH1A1KDM4EHSD17B10MEN1 | |
| SCHEMBL28579723 | 0.83 | DPP4 (0.40) | DPP4ALDH1A1KDM4EHSD17B10MEN1 | |
| SCHEMBL3735504 | 0.82 | DPP4 (0.43) | DPP4ALDH1A1KDM4EHSD17B10MEN1 | |
| SCHEMBL1358784 | 0.81 | DPP4 (0.54) | DPP4ALDH1A1KDM4EHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 392 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250368967-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | CODEXIS, INC. (US) | 2025-12-04 | — | — | US | claimed |
| US-12415990-B2 | Ketoreductase polypeptides for the reduction of acetophenones | CODEXIS, INC. (US) | 2025-09-16 | — | — | US | claimed |
| CN-119662581-A | Carbonyl reductase BsCR mutant, engineering bacterium and application of chiral intermediate for synthesizing crizotinib | 浙江工业大学 | 2025-03-21 | — | — | CN | claimed |
| CN-116496140-B | Preparation method of tenidine drug intermediate | 凯特立斯（深圳）科技有限公司 | 2025-03-04 | — | — | CN | claimed |
| CN-118771968-B | Method for separating and utilizing 2, 4-dichloro-5-fluoro acetophenone mother liquor | 山东国邦药业有限公司 | 2025-01-28 | — | — | CN | claimed |
| CN-117402055-B | Resource utilization method of 2, 4-dichloro-5-fluoroacetophenone mother liquor | 浙江吉泰新材料股份有限公司 | 2024-10-29 | — | — | CN | claimed |
| CN-114213630-B | Mannich modified amine epoxy resin curing agent and preparation method thereof | 上海船舶工艺研究所(中国船舶集团有限公司第十一研究所) | 2024-04-05 | — | — | CN | claimed |
| CN-117736083-A | Method for preparing 2, 4-dichloro-5-fluorobenzoic acid and 2, 6-dichloro-3-fluorobenzoic acid by taking 2, 4-dichloro-5-fluoroacetophenone crystallization mother liquor as raw material | 浙江工业大学 | 2024-03-22 | — | — | CN | claimed |
| CN-117486674-A | Comprehensive utilization method of 2, 4-dichloro-5-fluoroacetophenone crystallization mother liquor | 浙江工业大学 | 2024-02-02 | — | — | CN | claimed |
| CN-117402055-A | Resource utilization method of 2, 4-dichloro-5-fluoroacetophenone mother liquor | 浙江吉泰新材料股份有限公司 | 2024-01-16 | — | — | CN | claimed |
| US-20130344552-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | CODEXIS, INC. (US) | 2013-12-26 | — | — | US | claimed |
| EP-2198018-B1 | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | CODEXIS INC (US) | 2013-11-20 | — | — | EP | claimed |
| US-8512973-B2 | Methods of using engineered ketoreductase polypeptides for the stereoselective reduction of acetophenones | CODEXIS, INC. (US) | 2013-08-20 | — | — | US | claimed |
| US-20130078692-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | CODEXIS, INC. (US) | 2013-03-28 | — | — | US | claimed |
| EP-2198018-A2 | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | Codexis, Inc. (US) | 2010-06-23 | — | — | EP | claimed |
| US-20090191605-A1 | Ketoreductase Polypeptides for the Reduction of Acetophenones | CODEXIS, INC. (US) | 2009-07-30 | — | — | US | claimed |
| WO-2009036404-A2 | KETOREDUCTASE POLYPEPTIDES FOR THE REDUCTION OF ACETOPHENONES | CODEXIS, INC. (US) | 2009-03-19 | — | — | WO | claimed |
| EP-1791965-A1 | ENANTIOSELECTIVE BIOTRANSFORMATION FOR PREPARATION OF PROTEIN TYROSINE KINASE INHIBITOR INTERMEDIATES | Pfizer, Inc. (US) | 2007-06-06 | — | — | EP | claimed |
| WO-2006021885-A1 | ENANTIOSELECTIVE BIOTRANSFORMATION FOR PREPARATION OF PROTEIN TYROSINE KINASE INHIBITOR INTERMEDIATES | PFIZER INC. (US) | 2006-03-02 | — | — | WO | claimed |
| US-20060046287-A1 | Enantioselective biotransformation for preparation of protein tyrosine kinase inhibitor intermediates | AGOURON PHARMACEUTICALS, INC. | 2006-03-02 | — | — | US | claimed |