Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL489037 | 0.87 | CYP3A4 (0.38) | HSD17B10CYP3A4HPGDHIF1AMAPK1 | |
| SCHEMBL488903 | 0.78 | CYP3A4 (0.50) | HSD17B10CYP3A4HPGDHIF1AMAPK1 | |
| SCHEMBL31283575 | 0.78 | CYP3A4 (0.50) | HSD17B10CYP3A4HPGDHIF1AMAPK1 | |
| SCHEMBL17417161 | 0.74 | TP53 (0.43) | HSD17B10CYP3A4HPGDHIF1ATSHR | |
| SCHEMBL9845792 | 0.68 | HPGD (0.54) | HSD17B10CYP3A4HPGDHIF1AMAPK1 | |
| SCHEMBL13763201 | 0.68 | PTPN22 (0.55) | HSD17B10CYP3A4HPGDHIF1AMAPK1 | |
| SCHEMBL18013749 | 0.67 | CYP3A4 (0.53) | HSD17B10CYP3A4HPGDHIF1AMAPK1 | |
| SCHEMBL14008502 | 0.67 | MEN1 (0.41) | HSD17B10CYP3A4MAPK1TSHRRAB9A | |
| SCHEMBL3991314 | 0.67 | IDO1 (0.52) | HSD17B10HPGDTSHRCASP1CYP1A2 | |
| SCHEMBL1101881 | 0.66 | LMNA (0.52) | HSD17B10CYP3A4HPGDHIF1AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8105836-B2 | Chemical inhibitors of mismatch repair | MORPHOTEK, INC. (US) | 2012-01-31 | — | — | US | claimed |
| EP-1351565-B1 | CHEMICAL INHIBITORS OF MISMATCH REPAIR | MORPHOTEK INC (US) | 2011-03-16 | — | — | EP | claimed |
| US-6982169-B2 | Chemical inhibitors of mismatch repair | MORPHOTEK, INC. (US) | 2006-01-03 | — | — | US | claimed |
| EP-1351565-A4 | CHEMICAL INHIBITORS OF MISMATCH REPAIR | MORPHOTEK INC (US) | 2005-05-25 | — | — | EP | claimed |
| EP-1417329-A4 | METHODS FOR GENERATING ANTIBIOTIC RESISTANT MICROBES AND NOVEL ANTIBIOTICS | MORPHOTEK INC (US) | 2005-05-11 | — | — | EP | claimed |
| EP-1417329-A1 | METHODS FOR GENERATING ANTIBIOTIC RESISTANT MICROBES AND NOVEL ANTIBIOTICS | Morphotek Inc. (US) | 2004-05-12 | — | — | EP | claimed |
| EP-1351565-A1 | CHEMICAL INHIBITORS OF MISMATCH REPAIR | Morphotek Inc. (US) | 2003-10-15 | — | — | EP | claimed |
| US-20030143586-A1 | Genetic hypermutability of plants for gene discovery and diagnosis | MORPHOTEK, INC. | 2003-07-31 | — | — | US | claimed |
| US-20030091997-A1 | Chemical inhibitors of mismatch repair | EISAI, INC. | 2003-05-15 | — | — | US | claimed |
| WO-2003031937-A2 | GENETIC HYPERMUTABILITY OF PLANTS FOR GENE DISCOVERY AND DIAGNOSIS | MORPHOTEK, INC. (US) | 2003-04-17 | — | — | WO | claimed |
| US-20030068808-A1 | Methods for generating antibiotic resistant microbes and novel antibiotics | MORPHOTEK, INC. | 2003-04-10 | — | — | US | claimed |
| WO-2003012130-A1 | METHODS FOR GENERATING ANTIBIOTIC RESISTANT MICROBES AND NOVEL ANTIBIOTICS | MORPHOTEK INC. (US) | 2003-02-13 | — | — | WO | claimed |
| WO-2002054856-A1 | CHEMICAL INHIBITORS OF MISMATCH REPAIR | MORPHOTEK INC. (US) | 2002-07-18 | — | — | WO | claimed |
| US-10023632-B2 | Antigenic GM-CSF peptides and antibodies to GM-CSF | MORPHOTEK, INC. (US) | 2018-07-17 | — | — | US | disclosed |
| EP-3181585-A2 | ANTIGENIC GM-CSF PEPTIDES AND ANTIBODIES TO GM-CSF | Morphotek, Inc. (US) | 2017-06-21 | — | — | EP | disclosed |
| US-20160333089-A1 | Antigenic GM-CSF Peptides and Antibodies to GM-CSF | EISAI, INC. | 2016-11-17 | — | — | US | disclosed |
| WO-2003031937-A2 | GENETIC HYPERMUTABILITY OF PLANTS FOR GENE DISCOVERY AND DIAGNOSIS | MORPHOTEK, INC. (US) | 2003-04-17 | — | — | WO | disclosed |
| US-20030068808-A1 | Methods for generating antibiotic resistant microbes and novel antibiotics | MORPHOTEK, INC. | 2003-04-10 | — | — | US | disclosed |
| WO-2003012130-A1 | METHODS FOR GENERATING ANTIBIOTIC RESISTANT MICROBES AND NOVEL ANTIBIOTICS | MORPHOTEK INC. (US) | 2003-02-13 | — | — | WO | disclosed |
| WO-2002054856-A1 | CHEMICAL INHIBITORS OF MISMATCH REPAIR | MORPHOTEK INC. (US) | 2002-07-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160333089-A1 | Antigenic GM-CSF Peptides and Antibodies to GM-CSF | CSF3R, CSF1R, GMFG | HSD17B10 4026/4885CYP3A4 4877/4885HPGD 2997/4885 |
| US-10023632-B2 | Antigenic GM-CSF peptides and antibodies to GM-CSF | CSF3R, CSF1R, GMFG | HSD17B10 4026/4885CYP3A4 4877/4885HPGD 2997/4885 |
| US-20030091997-A1 | Chemical inhibitors of mismatch repair | MSH2, MSH6, PMS2 | HSD17B10 2040/4885CYP3A4 4098/4885HPGD 843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.