Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7610256 | 0.85 | ALDH1A1 (0.42) | ALDH1A1MAPK1KMT2AMEN1CYP2C19 | |
| Hydrochloric Acid SCHEMBL3847558 | 0.84 | ALDH1A1 (0.42) | ALDH1A1MAPK1KMT2AMEN1CYP2C19 | |
| SCHEMBL9489213 | 0.83 | ALDH1A1 (0.48) | ALDH1A1NPSR1MAPK1KMT2AMEN1 | |
| SCHEMBL9489209 | 0.83 | ALDH1A1 (0.48) | ALDH1A1NPSR1MAPK1KMT2AMEN1 | |
| SCHEMBL31437669 | 0.81 | NTMT1 (0.50) | ALDH1A1 | |
| Glycyl Proline SCHEMBL10589539 | 0.81 | CYP1A2 (0.43) | ALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL10589601 | 0.81 | HTT (0.52) | ALDH1A1NPSR1MAPK1CYP2C9CYP2C19 | |
| SCHEMBL380892 | 0.81 | HTT (0.52) | ALDH1A1NPSR1MAPK1CYP2C9CYP2C19 | |
| SCHEMBL9489177 | 0.79 | ALDH1A1 (0.47) | ALDH1A1NPSR1MAPK1KMT2AMEN1 | |
| SCHEMBL9489174 | 0.79 | ALDH1A1 (0.47) | ALDH1A1NPSR1MAPK1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170035938-A1 | PREPARATIVE REGIMEN FOR ENGRAFTMENT, GROWTH AND DIFFERENTIATION OF NON-HEMATOPOEITIC CELLS IN VIVO AFTER TRANSPLANTATION | VARIAN MED SYS INC (US) | 2017-02-09 | — | — | US | disclosed |
| US-9314486-B2 | Preparative regimen for engraftment, growth and differentiation of non-hematopoeitic cells in vivo after transplantation | VARIAN MEDICAL SYSTEMS, INC. (US) | 2016-04-19 | — | — | US | disclosed |
| US-20130149280-A1 | PREPARATIVE REGIMEN FOR ENGRAFTMENT, GROWTH AND DIFFERENTIATION OF NON-HEMATOPOEITIC CELLS IN VIVO AFTER TRANSPLANTATION | MONTEFIORE MEDICAL CENTER (US) | 2013-06-13 | — | — | US | disclosed |
| US-20080233088-A1 | PREPARATIVE REGIMEN FOR ENGRAFTMENT, GROWTH AND DIFFERENTIATION OF NON-HEMATOPOEITIC CELLS IN VIVO AFTER TRANSPLANTATION | VARIAN MEDICAL SYSTEMS TECHNOLOGIES, INC. (US) | 2008-09-25 | — | — | US | disclosed |
| WO-2008101215-A1 | PREPARATIVE REGIMEN FOR ENGRAFTMENT, GROWTH AND DIFFERENTIATION OF NON-HEMATOPOEITIC CELLS IN VIVO | VARIAN MEDICAL SYSTEMS TECHNOLOGIES, INC. (US) | 2008-08-21 | — | — | WO | disclosed |
| EP-0967285-B1 | expression vector for prolylendopeptidase from Flavobacterium meningosepticum | NOVARTIS AG (CH) | 2007-09-12 | — | — | EP | disclosed |
| EP-0967285-A1 | Prolylendopeptidase from Flavobacterium meningosepticum | Ciba-Geigy Japan Limited (JP) | 1999-12-29 | — | — | EP | disclosed |
| US-5521081-A | DNA molecule encoding prokaryotic prolylendopeptidase | CIBA-GEIGY (JAPAN) LIMITED (JP) | 1996-05-28 | — | — | US | disclosed |
| EP-0524906-A1 | DNA coding for prolylendopeptidase | CIBA-GEIGY (JAPAN) LIMITED (JP) | 1993-01-27 | — | — | EP | disclosed |
| US-4994376-A | Using N-carbobenzoxy-glycyl-glycyl-arginine-B-naphthylamide | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NY (US) | 1991-02-19 | — | — | US | disclosed |
| EP-0292708-A2 | Detection of Bacteroides gingivalis | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1988-11-30 | — | — | EP | disclosed |
| EP-0122023-A1 | Microorganisms detection methods and the separation of agglutinated microorganisms, and a kit for use therein | E-Y LABORATORIES, INC. (US) | 1984-10-17 | — | — | EP | disclosed |