Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4895122 | 0.85 | P2RX7 (0.44) | SMN1; SMN2ALDH1A1POLBKDM4EKMT2A | |
| SCHEMBL4898783 | 0.81 | AAK1 (0.51) | SMN1; SMN2ALDH1A1POLBKDM4ELMNA | |
| SCHEMBL4894721 | 0.77 | AAK1 (0.43) | SMN1; SMN2ALDH1A1POLBKDM4ELMNA | |
| SCHEMBL4890917 | 0.73 | KDM4E (0.41) | SMN1; SMN2ALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL4884321 | 0.72 | KDM4E (0.47) | SMN1; SMN2ALDH1A1POLBKDM4ELMNA | |
| SCHEMBL14087734 | 0.72 | MEN1 (0.44) | SMN1; SMN2ALDH1A1POLBKDM4ELMNA | |
| SCHEMBL4884311 | 0.71 | KDM4E (0.48) | SMN1; SMN2ALDH1A1POLBKDM4ELMNA | |
| SCHEMBL14112953 | 0.71 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1KDM4ELMNAKMT2A | |
| SCHEMBL14087733 | 0.70 | POLB (0.48) | SMN1; SMN2ALDH1A1POLBKDM4ELMNA | |
| SCHEMBL4882718 | 0.70 | KDM4E (0.55) | SMN1; SMN2ALDH1A1POLBKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200512-A1 | Hepatitis C virus polymerase inhibitors | BLANEY JEFFREY MARK | 2008-08-21 | — | — | US | disclosed |
| US-20080200512-A1 | Hepatitis C virus polymerase inhibitors | BLANEY JEFFREY MARK | 2008-08-21 | — | — | US | disclosed |
| US-20080200512-A1 | Hepatitis C virus polymerase inhibitors | BLANEY JEFFREY MARK | 2008-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200512-A1 | Hepatitis C virus polymerase inhibitors | SSU72, POLR2H, POLR2E | SMN1; SMN2 4735/4885ALDH1A1 276/4885POLB 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.