Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.45 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.44 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 7/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.40 |
| ▸ | ATXN2 | Q99700 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20955202 | 0.81 | XIAP (0.46) | HDAC1HDAC8HDAC6NPC1L1XIAP | |
| SCHEMBL4890372 | 0.80 | P2RY1 (0.37) | HDAC1HDAC6P2RY1RORC | |
| Trifluoroacetic Acid SCHEMBL4762245 | 0.78 | P2RY1 (0.37) | HDAC1HDAC6P2RY1TACR1 | |
| SCHEMBL4893251 | 0.78 | P2RY1 (0.36) | HDAC1HDAC6P2RY1RORC | |
| SCHEMBL4821789 | 0.78 | P2RY1 (0.39) | HDAC1HDAC6P2RY1RORC | |
| SCHEMBL4881720 | 0.78 | NOTUM (0.38) | RORCBACE1NPSR1TACR1RAB9A | |
| SCHEMBL2625791 | 0.77 | HDAC1 (0.50) | HDAC1HDAC8HDAC6XIAPBIRC2 | |
| SCHEMBL4974614 | 0.77 | HDAC1 (0.50) | HDAC1HDAC8HDAC6XIAPBIRC2 | |
| Trifluoroacetic Acid SCHEMBL4761896 | 0.77 | OPRM1 (0.36) | HDAC1HDAC6P2RY1TACR1 | |
| SCHEMBL5579105 | 0.77 | OPRM1 (0.42) | P2RY1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200491-A1 | 1,2-Dihydro-Spiro[3H-Indole-3,4'-Piperidine] Compounds, as Modulators of the Mas Receptor Novel | ARENA PHARMACEUTICALS, INC. | 2008-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200491-A1 | 1,2-Dihydro-Spiro[3H-Indole-3,4'-Piperidine] Compounds, as Modulators of the Mas Receptor Novel | AGTR1, AGTR2, AVPR2 | HDAC1 418/4885HDAC8 1226/4885HDAC6 835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.