Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | TYMP | P19971 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | FDPS | P14324 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.32 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4891023 | 0.83 | DHFR (0.33) | DHFRTYMPCDK2CCNE2CCNE1 | |
| SCHEMBL11589765 | 0.72 | CCNE2 (0.50) | CDK2CCNE2CCNE1ALDH1A1HPGD | |
| Naphthalene SCHEMBL11589769 | 0.71 | CYP2A6 (0.36) | MAPTADKRAB9A | |
| SCHEMBL4891000 | 0.69 | NPC1 (0.37) | DHFRCDK2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL3837800 | 0.68 | CCNE2 (0.30) | CDK2CCNE2CCNE1 | |
| SCHEMBL3064895 | 0.68 | ALDH1A1 (0.50) | CDK2CCNE2CCNE1ALDH1A1HSD17B10 | |
| SCHEMBL2554754 | 0.68 | ALDH1A1 (0.50) | CDK2CCNE2CCNE1ALDH1A1HSD17B10 | |
| Azobenzene SCHEMBL11590710 | 0.68 | ALDH1A1 (0.50) | CDK2CCNE2CCNE1ALDH1A1HSD17B10 | |
| SCHEMBL27330089 | 0.66 | ALDH1A1 (0.48) | CDK2CCNE2CCNE1ALDH1A1HSD17B10 | |
| SCHEMBL2108116 | 0.66 | GAA (0.57) | CDK2CCNE2CCNE1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312238-A1 | 4-Arylazo-3,5-Diamino-Pyrazole Compounds and Use Thereof | INSTITUTE OF EXPERIMENTAL BONTANY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC, V.V.I. (CZ) | 2008-12-18 | — | — | US | claimed |
| EP-1786779-A1 | 4-ARYLAZO-3,5-DIAMINO-PYRAZOLE COMPOUNDS AND USE THEREOF | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2007-05-23 | — | — | EP | claimed |
| WO-2006024858-A1 | 4-ARYLAZO-3,5-DIAMINO-PYRAZOLE COMPOUNDS AND USE THEREOF | INSTITUTE OF EXPERIMENTAL BOTANY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 2006-03-09 | — | — | WO | claimed |
| US-8357673-B2 | 4-arylazo-3,5-diamino-pyrazole compounds and use thereof | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2013-01-22 | — | — | US | disclosed |
| US-20080312238-A1 | 4-Arylazo-3,5-Diamino-Pyrazole Compounds and Use Thereof | INSTITUTE OF EXPERIMENTAL BONTANY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC, V.V.I. (CZ) | 2008-12-18 | — | — | US | disclosed |
| EP-1786779-A1 | 4-ARYLAZO-3,5-DIAMINO-PYRAZOLE COMPOUNDS AND USE THEREOF | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006024858-A1 | 4-ARYLAZO-3,5-DIAMINO-PYRAZOLE COMPOUNDS AND USE THEREOF | INSTITUTE OF EXPERIMENTAL BOTANY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 2006-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312238-A1 | 4-Arylazo-3,5-Diamino-Pyrazole Compounds and Use Thereof | CDK9, CDK3, CDK19 | DHFR 105/4885TYMP 409/4885CDK2 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.