Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 6/20 | 0.59 |
| ▸ | HTR1A | P08908 | 5/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.59 |
| ▸ | HTR1D | P28221 | 3/20 | 0.59 |
| ▸ | HTR1B | P28222 | 3/20 | 0.59 |
| ▸ | HTR2C | P28335 | 3/20 | 0.59 |
| ▸ | HTR7 | P34969 | 3/20 | 0.59 |
| ▸ | HTR6 | P50406 | 3/20 | 0.59 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 2/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.57 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.56 |
| ▸ | HTR2B | P41595 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6527354 | 0.82 | CYP1A2 (0.57) | HTR2AHTR1ACYP1A2CYP2D6HTR1D | |
| SCHEMBL6535395 | 0.82 | GSK3B (0.54) | HTR2ACYP1A2CYP2D6HTR1DHTR1B | |
| SCHEMBL14197267 | 0.82 | MEN1 (0.56) | HTR2AHTR1ACYP1A2CYP2D6HTR1D | |
| SCHEMBL15128313 | 0.80 | HTR2A (0.73) | HTR2AHTR1ACYP1A2CYP2D6HTR1D | |
| SCHEMBL13240228 | 0.79 | HTR2A (0.68) | HTR2AHTR1ACYP1A2CYP2D6HTR1D | |
| SCHEMBL25082440 | 0.77 | HTR2A (0.68) | HTR2AHTR1ACYP1A2CYP2D6HTR1D | |
| SCHEMBL8717491 | 0.77 | HTR1A (0.73) | HTR2AHTR1ACYP1A2CYP2D6HTR1D | |
| SCHEMBL24723360 | 0.76 | GPR84 (0.69) | HTR2AHTR1ACYP1A2CYP2D6HTR1D | |
| SCHEMBL30942572 | 0.76 | GPR84 (0.69) | HTR2AHTR1ACYP1A2CYP2D6HTR1D | |
| SCHEMBL6923232 | 0.76 | HTR2A (0.72) | HTR2AHTR1ACYP1A2CYP2D6HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7355054-B2 | Indole derivatives | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2008-04-08 | — | — | US | disclosed |
| US-20050159463-A1 | Indole derivatives | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2005-07-21 | — | — | US | disclosed |
| EP-1189583-B1 | INDOLE DERIVATIVES | NEURIM PHARMA 1991 (IL) | 2005-07-20 | — | — | EP | disclosed |
| EP-1189583-A4 | INDOLE DERIVATIVES | NEURIM PHARMA 1991 (IL) | 2004-04-14 | — | — | EP | disclosed |
| EP-1189583-A1 | INDOLE DERIVATIVES | NEURIM PHARMACEUTICALS (1991) LIMITED (IL) | 2002-03-27 | — | — | EP | disclosed |
| WO-2000072815-A1 | INDOLE DERIVATIVES | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2000-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159463-A1 | Indole derivatives | IDO1, IDO2, H1-0 | HTR2A 56/4885HTR1A 27/4885CYP1A2 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.