Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 5/20 | 0.66 |
| ▸ | CD44 | P16070 | 1/20 | 0.66 |
| ▸ | MAOB | P27338 | 1/20 | 0.66 |
| ▸ | ASIC3 | Q9UHC3 | 4/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | PRCP | P42785 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.50 |
| ▸ | CFD | P00746 | 1/20 | 0.49 |
| ▸ | F11 | P03951 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30593253 | 0.96 | PNMT (0.59) | PNMTCD44MAOBASIC3ADRA2A | |
| SCHEMBL4663734 | 0.96 | PNMT (0.59) | PNMTCD44MAOBASIC3ADRA2A | |
| SCHEMBL6347388 | 0.93 | ASIC3 (0.65) | PNMTCD44MAOBASIC3PRCP | |
| Biphenyl SCHEMBL27799394 | 0.89 | PNMT (0.83) | PNMTCD44MAOBASIC3ADRA2A | |
| SCHEMBL29543554 | 0.85 | TYRO3 (0.50) | PNMTCD44MAOBASIC3CD274 | |
| SCHEMBL8676339 | 0.85 | TYRO3 (0.50) | PNMTCD44MAOBASIC3CD274 | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL19085 | 0.81 | PNMT (1.00) | PNMTCD44MAOBASIC3ADRA2A | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL29360217 | 0.81 | PNMT (1.00) | PNMTCD44MAOBASIC3ADRA2A | |
| 1,2,3,4-Tetrahydroisoquinoline SCHEMBL28236302 | 0.81 | PNMT (1.00) | PNMTCD44MAOBASIC3ADRA2A | |
| SCHEMBL7216445 | 0.81 | ASIC3 (0.54) | PNMTASIC3ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320989-B2 | Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-22 | — | — | US | disclosed |