Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4890923 | 0.90 | CHEK2 (0.46) | GPR119CHEK2PDE4B | |
| SCHEMBL4786440 | 0.90 | CHEK2 (0.46) | GPR119CHEK2PDE4B | |
| SCHEMBL4786833 | 0.86 | ALDH1A1 (0.44) | ALDH1A1HTT | |
| SCHEMBL4745663 | 0.84 | GPR119 (0.53) | GPR119CHEK2PDE4APDE4BPDE4C | |
| SCHEMBL14127666 | 0.82 | GPR119 (0.51) | GPR119CHEK2PDE4APDE4BPDE4C | |
| SCHEMBL20137483 | 0.80 | GPR119 (0.52) | GPR119CHEK2 | |
| SCHEMBL21606937 | 0.80 | GPR119 (0.52) | GPR119CHEK2 | |
| SCHEMBL18475482 | 0.79 | GPR119 (0.51) | GPR119CHEK2PDE4APDE4BPDE4C | |
| SCHEMBL4264039 | 0.79 | GPR119 (0.51) | GPR119CHEK2PDE4APDE4BPDE4C | |
| SCHEMBL2775170 | 0.79 | GPR119 (0.54) | GPR119CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | WYETH (US) | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293712-A1 | Benzo[C][2,7]Naphtyridine Derivatives, Methods of Making Thereof and Methods of Use Thereof | PDPK1, PDK2, PDK3 | GPR119 2327/4885CHEK2 536/4885PDE4A 354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.