Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KLK7 | P49862 | 2/20 | 0.52 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.49 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4103836 | 0.90 | SYK (0.64) | SYKMAPTPOLBMAPK1L3MBTL1 | |
| SCHEMBL698615 | 0.90 | SYK (0.64) | SYKMAPTPOLBMAPK1L3MBTL1 | |
| SCHEMBL20364084 | 0.90 | SYK (0.74) | SYKMAPTPOLBMAPK1L3MBTL1 | |
| SCHEMBL20556374 | 0.89 | SYK (0.63) | SYKMAPTPOLBMAPK1L3MBTL1 | |
| SCHEMBL20358408 | 0.89 | SYK (0.72) | SYKMAPTL3MBTL1KLK7KLK5 | |
| SCHEMBL19345775 | 0.89 | SYK (0.63) | SYKMAPTPOLBMAPK1L3MBTL1 | |
| SCHEMBL20365967 | 0.89 | SYK (0.72) | SYKMAPTL3MBTL1KLK7KLK5 | |
| SCHEMBL20556328 | 0.89 | SYK (0.63) | SYKMAPTPOLBMAPK1L3MBTL1 | |
| SCHEMBL1134605 | 0.89 | SYK (0.63) | SYKMAPTPOLBMAPK1L3MBTL1 | |
| SCHEMBL15159959 | 0.88 | ATM (0.62) | SYKMAPTATMPAX8TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7402673-B2 | Diamine β2 adrenergic receptor agonists | THERAVANCE, INC. (US) | 2008-07-22 | — | — | US | disclosed |
| US-20080039495-A1 | Diamine Beta2 Adrenergic Receptor Agonists | THERAVANCE BIOPHARMA R&D IP, LLC | 2008-02-14 | — | — | US | disclosed |
| EP-1751086-A2 | DIAMINE ß2 ADRENERGIC RECEPTOR AGONISTS | Theravance, Inc. (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005121065-A2 | DIAMINE β2 ADRENERGIC RECEPTOR AGONISTS | THERAVANCE, INC. (US) | 2005-12-22 | — | — | WO | disclosed |
| US-20050272769-A1 | Diamine beta2 adrenergic receptor agonists | THERAVANCE, INC. (US) | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272769-A1 | Diamine beta2 adrenergic receptor agonists | ADRB2, ADRB1, ADRA2C | SYK 2923/4885MAPT 1868/4885POLB 905/4885 |
| US-20080039495-A1 | Diamine Beta2 Adrenergic Receptor Agonists | ADRB2, ADRB1, ADRA2C | SYK 2923/4885MAPT 1868/4885POLB 905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.