Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ITGB2 | P05107 | 16/20 | 0.44 |
| ▸ | ICAM1 | P05362 | 16/20 | 0.44 |
| ▸ | ITGAL | P20701 | 16/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5196357 | 0.89 | ITGB2 (0.44) | NPC1RAB9AMAPTHPGDTP53 | |
| SCHEMBL4890590 | 0.84 | ITGB2 (0.50) | ITGB2ICAM1ITGAL | |
| SCHEMBL4895579 | 0.83 | RAB9A (0.49) | NPC1RAB9AMAPTHPGDTP53 | |
| SCHEMBL5447059 | 0.83 | ITGB2 (0.66) | MAPTITGB2ICAM1ITGAL | |
| SCHEMBL5451150 | 0.82 | ITGB2 (0.67) | NPC1RAB9AMAPTHPGDITGB2 | |
| SCHEMBL5220946 | 0.81 | ITGB2 (0.67) | MAPTITGB2ICAM1ITGAL | |
| SCHEMBL4893719 | 0.81 | ITGB2 (0.63) | ITGB2ICAM1ITGAL | |
| SCHEMBL5451106 | 0.80 | ITGB2 (0.68) | MAPTITGB2ICAM1ITGAL | |
| SCHEMBL5453167 | 0.80 | ITGB2 (0.68) | MAPTITGB2ICAM1ITGALALDH1A1 | |
| SCHEMBL5446494 | 0.80 | ITGB2 (0.52) | ITGB2ICAM1ITGAL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234271-A1 | Arylphenylamino- and Arylphenylether-Sulfide Derivatives, Useful For the Treatment of Inflammatory and Immune Diseases, and Pharmaceutical Compositions Containing Them | ICOS CORPORATION (US) | 2008-09-25 | — | — | US | disclosed |
| US-20070259863-A1 | Arylphenylamino-,Arylphenylamide-, and Arylphenylether-Sulfide Derivatives | ICOS CORPORATION (US) | 2007-11-08 | — | — | US | disclosed |
| EP-1740561-A2 | ARYLPHENYLAMINO-AND ARYLPHENYLETHER-SULFIDE DERIVATIVES, USEFUL FOR THE TREATMENT OF INFLAMMATORY AND IMMUNE DISEASES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ICOS Corporation (US) | 2007-01-10 | — | — | EP | disclosed |
| EP-1740565-A2 | ARYLPHENYLAMINO-, ARYLPHENYLAMIDE-, AND ARYLPHENYLETHER-SUFIDE DERIVATIVES | ICOS Corporation (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105766-A2 | ARYLPHENYLAMINO-AND ARYLPHENYLETHER-SULFIDE DERIVATIVES, USEFUL FOR THE TREATMENT OF INFLAMMATORY AND IMMUNE DISEASES, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ICOS CORPORATION (US) | 2005-11-10 | — | — | WO | disclosed |
| WO-2005105770-A2 | ARYLPHENYLAMINO-, ARYLPHENYLAMIDE-, AND ARYLPHENYLETHER-SULFIDE DERIVATIVES | ICOS CORPORATION (US) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259863-A1 | Arylphenylamino-,Arylphenylamide-, and Arylphenylether-Sulfide Derivatives | AHR, ARSA, TST | NPC1 2015/4885RAB9A 3940/4885MAPT 3469/4885 |
| US-20080234271-A1 | Arylphenylamino- and Arylphenylether-Sulfide Derivatives, Useful For the Treatment of Inflammatory and Immune Diseases, and Pharmaceutical Compositions Containing Them | HPGDS, AHR, TST | NPC1 1906/4885RAB9A 3502/4885MAPT 3581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.